The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients

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dc.authoridBakiye Okumuş / 0000-0003-2480-1374en_US
dc.authorwosidBakiye Okumuş / N-6785-2018
dc.contributor.authorAkbaş, Ahmet
dc.contributor.authorAydın Kasap, Zeliha
dc.contributor.authorHacim, Nadir Adnan
dc.contributor.authorTokoçin, Merve
dc.contributor.authorAltınel, Yüksel
dc.contributor.authorYiğitbaş, Hakan
dc.contributor.authorMeriç, Serhat
dc.contributor.authorOkumuş, Bakiye
dc.date.accessioned2020-09-24T13:45:58Z
dc.date.available2020-09-24T13:45:58Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBACKGROUND: Acute appendicitis (AA) is the most common extra-obstetric condition requiring surgery during pregnancy. AA diagnosis is made by laboratory tests along with anamnesis and physical examination findings. Due to the physiological and anatomical changes during the pregnancy, AA diagnosis is more challenging in pregnant women compared to non-pregnant patients. The present study evaluated the significance of white blood cell counts (WBC), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR) and lymphocyte-to-C-reactive protein ratio (LCR) to diagnose acute appendicitis during pregnancy. METHODS: Pregnant patients admitted to General Surgery Inpatient Clinic with AA pre-diagnosis in September 2015-December 2019 period were screened using International Statistical Classification of Diseases and Related Health Problems-10 (ICD-10) diagnosis code (K35= acute appendicitis, Z33= pregnancy), and AA patients were identified retrospectively. The patients were divided into two groups. The Group I included the patients who had appendectomy due to AA and had a suppurative appendicitis diagnosis based on the pathological evaluation. On the other hand, Group II had the patients admitted as an inpatient with AA pre-diagnosis, but discharged from the hospital with full recovery without operation. Group III, i.e., the control group, on the other hand, was constituted by 32 randomly and prospectively recruited healthy pregnant women who were willing to participate in the study and who had matching study criteria among the patients followed in Obstetrics and Gynecology outpatient clinic of our hospital. RESULTS: This study included 96 pregnant women with an average age of 29.20±4.47 years (32 healthy pregnant women, 32 pregnant women followed for acute abdominal observation and 32 pregnant women who underwent appendectomy). Of these patients, three cases who turned out not to have suppurative appendicitis (negative appendectomy) and two cases found to have perforated appendicitis based on intraoperative and histopathological evaluations were excluded from this study. The results showed that Group I patients had significantly higher WBC (p=0.001), CAR (p=0.001) and NLR (p=0.001), but significantly lower LCR values (p=0.001) compared to the Groups II and III. Besides, based on logistic regression analysis, it was revealed that higher WBC, CAR and NLR values and lower LCR values were independent variables that could be used for the diagnosis of AA in pregnant women. CONCLUSION: Considering WBC, NLR, CAR and LCR parameters in addition to medical history, physical examination and imaging techniques could help clinicians diagnose acute appendicitis in pregnant women. © 2020 Turkish Association of Trauma and Emergency Surgery.en_US
dc.identifier.citationAkbaş, A., Aydın Kasap, Z., Hacım, N. A., Tokoçin, M., Altınel, Y., Yiğitbaş, H., . . . Okumuş, B. (2020). The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients. [Gebe hastalarda enflamatuvar belirteçlerin akut apandisit tanısı koymadaki değeri] Ulusal Travma Ve Acil Cerrahi Dergisi, 26(5), 769-776. doi:10.14744/tjtes.2020.03456en_US
dc.identifier.doi10.14744/tjtes.2020.03456en_US
dc.identifier.endpage776en_US
dc.identifier.issn1306696Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid32946079en_US
dc.identifier.scopus2-s2.0-85091037950en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage769en_US
dc.identifier.trdizinid372946en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.03456
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1083
dc.identifier.volume26en_US
dc.identifier.wosWOS:000580594400019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOkumuş, Bakiye
dc.language.isoenen_US
dc.relation.ispartofTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Appendicitisen_US
dc.subjectCRP Albumin Ratioen_US
dc.subjectLymphocyteen_US
dc.subjectNeutrophilen_US
dc.subjectPregnancyen_US
dc.titleThe value of inflammatory markers in diagnosing acute appendicitis in pregnant patientsen_US
dc.title.alternativeGebe hastalarda enflamatuvar belirteçlerin akut apandisit tanısı koymadaki değerien_US
dc.typeArticleen_US

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