The investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissue

dc.authoridİlknur Dursun / 0000-0001-7094-3336en_US
dc.authorscopusidİlknur Dursun / 15126492700
dc.authorwosidİlknur Dursun / AGW-2134-2022en_US
dc.contributor.authorAlgburi, Ali Forat
dc.contributor.authorDursun, İlknur
dc.contributor.authorUstaoğlu, Şebnem Garip
dc.date.accessioned2022-12-02T07:38:47Z
dc.date.available2022-12-02T07:38:47Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOne of the most common causes of fetal alcohol spectrum disease (FASD) characterized with neuro-developmental disorder and growth retardation, is the postnatal alcohol consumption. Since studies in literature are mainly focused on alcohol-induced effects on brain tissues, the molecular effects of postnatal alcohol con-sumption on fetal liver are not clarified yet. The aim of this study is to determine the postnatal alcohol consumption-induced structural and compositional changes on liver tissue and the antioxidant capacity of liver. Newborn mice were divided into 3 groups as control group without any treatment, alcohol group treated with 3.0 g/kg of ethanol in 0.02 ml/g of artificially enriched milk between Postnatal Days (PD) 3-20 and intragastric intubation control group which was intragastrically intubated in the same method as the alcohol group but without ethanol/milk. These postnatal days in mice refers prenatal period (third trimester) of gestation in human. The biomolecular changes were determined by ATR-FTIR spectral analysis of the samples, besides the biochemical measurement of total protein content and antioxidant capacity of liver tissue. The result of the current study shows that while there was a slight increase in total lipid content, significant decrease in unsat-urated lipid and total protein contents and total antioxidant capacity of liver were observed in alcohol-treated group. Thus, it is concluded that postnatal alcohol treatment causes significant changes in tissue proteins and lipids by inducing lipid peroxidation and changes in protein conformations of the liver tissue. In addition to that alcohol consumption also reduce the antioxidant capacity of liver tissue.en_US
dc.identifier.citationAlgburi, A. F., Dursun, I., & Ustaoglu, S. G. (2022). The investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissue. Life Sciences, 310, 121102.en_US
dc.identifier.doi10.1016/j.lfs.2022.121102en_US
dc.identifier.issn0024-3205en_US
dc.identifier.issn1879-0631en_US
dc.identifier.scopus2-s2.0-85141892007en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.lfs.2022.121102
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3400
dc.identifier.volume310en_US
dc.identifier.wosWOS:000880621100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDursun, İlknur
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofLIFE SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPostnatal Alcohol Consumptionen_US
dc.subjectIntragastric İntubationen_US
dc.subjectATR-FTIR Spectroscopyen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectMiceen_US
dc.subjectLiveren_US
dc.titleThe investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissueen_US
dc.typeArticleen_US

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