Determination of capsaicin at trace levels in different food, biological and environmental samples by quadruple isotope dilution-gas chromatography mass spectrometry after its preconcentration

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dc.authorscopusidSüleyman Bodur / 57202493954
dc.authorwosidSüleyman Bodur / AHB-4581-2022
dc.contributor.authorBodur, Sezin Erarpat
dc.contributor.authorBodur, Süleyman
dc.contributor.authorAyyıldız, Merve Fırat
dc.contributor.authorGünkara, Ömer Tahir
dc.contributor.authorDikmen, Yaren
dc.contributor.authorDoru, Esra Sultan
dc.contributor.authorBakırdere, Sezgin
dc.date.accessioned2025-04-18T08:55:55Z
dc.date.available2025-04-18T08:55:55Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractDespite the therapeutic properties of capsaicin for some diseases, it shows some side effects for human health. The goal of this study was to develop a precise and accurate analytical strategy for the trace determination of capsaicin in different food, biological and environmental samples including pepper, saliva and wastewater by gas chromatography-mass spectrometry (GC-MS) after spraying-based fine droplet formation-liquid phase microextraction (SFDF-LPME) and quadruple isotope dilution (ID4) method. Acetic anhydride was used as derivatizing agent, and the extraction method was used to enrich the analyte derivative to reach low detection limits. Under the optimum conditions, limit of detection (LOD) and limit of quantitation (LOQ) were determined to be 0.33 and 1.10 mu g/kg, respectively. Percent recoveries calculated for SFDF-LPME-GC-MS method ranged between 84.1 and 131.7 %. After the application of ID4-SFDF-LPME-GC-MS method, percent recoveries were obtained in the range of 94.9 and 104.0 % (%RSD <= 2.8) for the selected samples. It is obvious that the isotope dilution-based method provided high accurate and precise results due to the elimination of errors during the derivatization, extraction and measurement steps.
dc.identifier.citationBodur, S. E., Bodur, S., Ayyıldız, M. F., Günkara, Ö. T., Dikmen, Y., Doru, E. S., & Bakırdere, S. (2024). Determination of capsaicin at trace levels in different food, biological and environmental samples by quadruple isotope dilution-gas chromatography mass spectrometry after its preconcentration. Journal of Chromatography A, 1731, 465147.
dc.identifier.doi10.1016/j.chroma.2024.465147
dc.identifier.issn0021-9673
dc.identifier.issn1873-3778
dc.identifier.pmid39038417
dc.identifier.scopus2-s2.0-85199057443
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.chroma.2024.465147
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6643
dc.identifier.volume1731
dc.identifier.wosWOS:001276419400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBodur, Süleyman
dc.institutionauthoridSüleyman Bodur / 0000-0002-2994-9047
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of chromatography a
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCapsaicin
dc.subjectDomestic Wastewater
dc.subjectMicroextraction
dc.subjectPepper
dc.subjectQuadruple Isotope Dilution
dc.titleDetermination of capsaicin at trace levels in different food, biological and environmental samples by quadruple isotope dilution-gas chromatography mass spectrometry after its preconcentration
dc.typeArticle

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