Efficacy of krill oil versus fish oil on obesity-related parameters and lipid gene expression in rats: randomized controlled study

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dc.authoridHalit Tanju Besler / 0000-0002-6523-7995en_US
dc.authorscopusidHalit Tanju Besler / 7004612803en_US
dc.authorwosidHalit Tanju Besler / I-9965-2013
dc.contributor.authorÇil, Mevra Aydın
dc.contributor.authorGhareaghaji, Atena Ghosi
dc.contributor.authorBayır, Yasin
dc.contributor.authorBüyüktuncer, Zehra
dc.contributor.authorBesler, Halit Tanju
dc.date.accessioned2021-10-07T11:52:39Z
dc.date.available2021-10-07T11:52:39Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractBackround. This study aimed to determine the effects of LC n-3 PUFA supplementation on the prevention and treatment of obesity and obesity-related diseases, and to compare the efficiency of different LC n-3PUFAsources via biochemical and genetic mechanisms in rats. Methods. Male Wistar rats were randomized into four study groups, and fed with a standard diet, High Fat Diet (HFD), HFD+%2.5 Fish Oil (FO-HFD) or HFD+%2.5 Krill Oil (KO-HFD) for eight weeks. Food consumption, weight gain, serum glucose, insulin, ghrelin and leptin concentrations, lipid profile, liver fatty acid composition, and FADS1 and FADS2 mRNA gene expression levels were measured. Results. Weight gain in each HFD group was significantly higher than control group (p<0:001), without any differences among them (p<0:05). LC n-3 PUFAs modified lipid profile, but not glucose tolerance. Serum leptin levels were significantly higher in HFD groups than in the control group, however, no difference in serum ghrelin levels was observed among the groups. Liver n-3 fatty acid desaturation activity was higher (p D 0:74), and liver total lipid content was lower (p D 0:86) in KO-HFD compared to FO-HFD. FADS1 gene expression was highest in the HFD group (p<0:001) while FADS2 gene expression was highest in the FO-HFD group (p<0:001). Conclusion. LC n-3 PUFAs, especially krill oil, had moderate effects on lipid profile, but limited effects on obesity related parameters, suggesting different effects of different sources on gene expression levels. Further randomized controlled trials are needed to determine the efficacy of different LC n-3PUFAsources in the prevention and treatment of obesity in humans.en_US
dc.identifier.citationMevra Aydin Cil, Atena Ghosi Ghareaghaji, Yasin Bayir, Zehra Buyuktuncer, & Halit Tanju Besler. (2021). Efficacy of krill oil versus fish oil on obesity-related parameters and lipid gene expression in rats: randomized controlled study. PeerJ, 9, e12009. https://doi.org/10.7717/peerj.12009en_US
dc.identifier.doi10.7717/peerj.12009en_US
dc.identifier.endpage20en_US
dc.identifier.issn2167- 8359en_US
dc.identifier.pmid34692241en_US
dc.identifier.scopus2-s2.0-85115983874en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.7717/peerj.12009
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2128
dc.identifier.volume9en_US
dc.identifier.wosWOS:000707244200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBesler, Halit Tanju
dc.language.isoenen_US
dc.publisherPeerJen_US
dc.relation.ispartofPeerJen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatty Acid Desaturaseen_US
dc.subjectFish Oilen_US
dc.subjectGene Expressionen_US
dc.subjectKrill Oilen_US
dc.subjectLC n-3 PUFAen_US
dc.subjectObesityen_US
dc.titleEfficacy of krill oil versus fish oil on obesity-related parameters and lipid gene expression in rats: randomized controlled studyen_US
dc.typeArticleen_US

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