Aloe vera-based antibacterial porous sponges for wound dressing applications

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidBurçin İzbudak / 57221779519
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.authorwosidBurçin İzbudak / GXP-7807-2022
dc.contributor.authorTamahkar, Emel
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorYarımcan, Filiz
dc.contributor.authorBoran, Filiz
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-02-08T07:49:05Z
dc.date.available2021-02-08T07:49:05Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractThe antibacterial sponges with high macroporosity, high interconnectivity and high biocompatibility is a significant concern for wound healing applications. In this work, novel Aloe vera (AV) based sponges were developed via subsequent lyophilization with further chemical crosslinking throughout the double network sponges. Single network was composed of gelatin-sodium alginate (G-SA) while the double network using gelatin-sodium alginate- sodium hyaluronate (G-SA-HA) was produced with the addition of hyaluronic acid solution into the gelatin-sodium alginate matrix. Lastly, Aloe vera as the bioactive agent was fabricated throughout the gelatin-sodium alginate-sodium hyaluronate matrix. The AV-based sponges demonstrated large pores with high interconnectivity. The swelling degree of the AV-based sponges were higher than that of G-SA and G-SA-HA sponges. The release of AV from the sponges reached an equilibrium value after 24 h showing a more controlled release at pH 5.5 than at pH 7.4. AV-based sponges showed antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae and Bacillus cereus and displayed any cytotoxicity against Mesenchymal stem cells.en_US
dc.identifier.citationTamahkar, E., Özkahraman, B., Özbaş, Z., İzbudak, B., Yarimcan, F., Boran, F., & Öztürk, A. B. (2021). Aloe vera-based antibacterial porous sponges for wound dressing applications. Journal of Porous Materials, 1-10.en_US
dc.identifier.doi10.1007/s10934-020-01029-1en_US
dc.identifier.issn1380-2224en_US
dc.identifier.issn1573-4854en_US
dc.identifier.scopus2-s2.0-85100181974en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10934-020-01029-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1423
dc.identifier.wosWOS:000608662700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF POROUS MATERIALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWound Dressingsen_US
dc.subjectHydrogelen_US
dc.subjectAntibacterial Spongeen_US
dc.subjectAloe Veraen_US
dc.titleAloe vera-based antibacterial porous sponges for wound dressing applicationsen_US
dc.typeArticleen_US

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