C-Reactive protein as a potential biomarker in psychiatric practice: are we there yet?
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Online
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Serum or plasma levels of C-reactive protein (CRP) and highsensitivity CRP (hsCRP) are widely used clinical markers of inflammation in other branches of medicine, whereas its clinical use in psychiatry has been limited to research studies. We aimed to assess the possibility of using CRP/hsCRP in psychiatric practice. This is a review and evaluation of various lines of evidence supporting the concept of CRP as a biomarker for psychiatric disorders in certain conditions. Methods: We searched the literature for studies which assessed CRP/hsCRP levels in various psychiatric disorders. Results: The accumulating evidence from large studies and meta-analyses allows us to understand the role of CRP in major psychiatric disorders and increase our understanding of specific symptoms and subtypes of disorders. CRP may be considered a “psychiatric biomarker” which can alert clinicians about neuroinflammation, adverse effects of medications, cardiometabolic status, comorbidities, and may also predict clinical outcomes and guide optimal treatment selection. Conclusion: Although the underlying pathophysiological role of CRP and hsCRP is still elusive and the association between CRP and psychiatric disorders is inconsistent, CRP holds promise to become a psychiatric biomarker.
Açıklama
Anahtar Kelimeler
C-reactive protein, CRP, hsCRP, Neuroinflammation, Psychiatry
Kaynak
The World Journal of Biological Psychiatry
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Erensu Baysak, Demet Sinem Guden, Feyza Aricioglu & Angelos Halaris
(2021): C-Reactive Protein as a Potential Biomarker in Psychiatric Practice: Are We There Yet?,
The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2021.1961502
