C-Reactive protein as a potential biomarker in psychiatric practice: are we there yet?

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dc.authoridDemet Sinem Güden / 0000-0001-5423-3641
dc.authorscopusidDemet Sinem Güden / 57113740400
dc.authorwosidDemet Sinem Güden / G-7606-2016
dc.contributor.authorBaysak, Erensu
dc.contributor.authorGüden, Demet Sinem
dc.contributor.authorArıcıoğlu, Feyza
dc.contributor.authorHalaris, Angelos
dc.date.accessioned2021-08-02T08:08:39Z
dc.date.available2021-08-02T08:08:39Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Serum or plasma levels of C-reactive protein (CRP) and highsensitivity CRP (hsCRP) are widely used clinical markers of inflammation in other branches of medicine, whereas its clinical use in psychiatry has been limited to research studies. We aimed to assess the possibility of using CRP/hsCRP in psychiatric practice. This is a review and evaluation of various lines of evidence supporting the concept of CRP as a biomarker for psychiatric disorders in certain conditions. Methods: We searched the literature for studies which assessed CRP/hsCRP levels in various psychiatric disorders. Results: The accumulating evidence from large studies and meta-analyses allows us to understand the role of CRP in major psychiatric disorders and increase our understanding of specific symptoms and subtypes of disorders. CRP may be considered a “psychiatric biomarker” which can alert clinicians about neuroinflammation, adverse effects of medications, cardiometabolic status, comorbidities, and may also predict clinical outcomes and guide optimal treatment selection. Conclusion: Although the underlying pathophysiological role of CRP and hsCRP is still elusive and the association between CRP and psychiatric disorders is inconsistent, CRP holds promise to become a psychiatric biomarker.en_US
dc.identifier.citationErensu Baysak, Demet Sinem Guden, Feyza Aricioglu & Angelos Halaris (2021): C-Reactive Protein as a Potential Biomarker in Psychiatric Practice: Are We There Yet?, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2021.1961502en_US
dc.identifier.doi10.1080/15622975.2021.1961502en_US
dc.identifier.endpage37en_US
dc.identifier.pmid34323645en_US
dc.identifier.scopus2-s2.0-85112308920en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/15622975.2021.1961502
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1972
dc.identifier.wosWOS:000684418100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüden, Demet Sinem
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofThe World Journal of Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-reactive proteinen_US
dc.subjectCRPen_US
dc.subjecthsCRPen_US
dc.subjectNeuroinflammationen_US
dc.subjectPsychiatryen_US
dc.titleC-Reactive protein as a potential biomarker in psychiatric practice: are we there yet?en_US
dc.typeArticleen_US

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