Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat

Basit Öğe Kaydı
dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridZeynep Püren Akgüner / 0000-0002-9626-1605
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidZeynep Püren Akgüner / 57205403842
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.authorwosidZeynep Püren Akgüner / CBX-7589-2022
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorKaral Yılmaz, Okşan
dc.contributor.authorPüren Akgüner, Zeynep
dc.contributor.authorAksu, Soner
dc.contributor.authorTaş, Arzu
dc.contributor.authorÖlmez, Hülya
dc.date.accessioned2020-08-30T20:06:49Z
dc.date.available2020-08-30T20:06:49Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractIn this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkiye)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [5143401]en_US
dc.description.sponsorshipFinancial support for this research was provided by the TUBITAK (The Scientific and Technological Research Council of Turkiye) project number 5143401.en_US
dc.identifier.citationBal-Ozturk, A., Karal-Yilmaz, O., Akguner, Z. P., Aksu, S., Tas, A., & Olmez, H. (2019). Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat. JOURNAL OF APPLIED POLYMER SCIENCE, 136(19). https://doi.org/10.1002/app.47522en_US
dc.identifier.doi10.1002/app.47522en_US
dc.identifier.issn0021-8995en_US
dc.identifier.issn1097-4628en_US
dc.identifier.issue19en_US
dc.identifier.scopus2-s2.0-85059886833en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.47522
dc.identifier.urihttps://hdl.handle.net/20.500.12713/627
dc.identifier.volume136en_US
dc.identifier.wosWOS:000458360000009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBal Öztürk, Ayçaen_US
dc.institutionauthorPüren Akgüner, Zeynepen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosan Hydrogelsen_US
dc.subjectGenipinen_US
dc.subjectHemorrhage Controlen_US
dc.subjectZno Nanoparticlesen_US
dc.titleSponge-like chitosan-based nanostructured antibacterial material as a topical hemostaten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
267.pdf
Boyut:
1.57 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Eczacılık Temel Bilimleri Bölümü Makale Koleksiyonu
Kök Hücre ve Doku Mühendisliği Programı Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu