IL-15 gene polymorphism in celiac disease patients and their siblings

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dc.authoridMakbule Eren / 0000-0002-7105-7165en_US
dc.authorscopusidMakbule Eren / 7006788428
dc.authorwosidMakbule Eren / AAD-8138-2019
dc.contributor.authorKara, Yalcin
dc.contributor.authorEren, Makbule
dc.contributor.authorArslan, Serap
dc.contributor.authorCilingir, Oguz
dc.date.accessioned2021-07-14T12:24:50Z
dc.date.available2021-07-14T12:24:50Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Celiac disease (CD) is an immune-mediated enteropathy characterized by lifelong gluten intolerance. Interleukin-15 (IL15) is a proinflammatory cytokine that is considered a key component in the immune reaction triggered by gluten. Our aim of this study was to evaluate the influence of IL-15 gene polymorphisms on CD development and clinical presentation. Methods: The study was enrolled-with 90 CD patients (49 female/41 male, median years of age 11), their 38 siblings (20 female/18 male, median years of age 8), and 99 healthy controls (66 female/33 male, median years of age 13). Their demographic findings, symptoms, and signs histopathological grade, Human Leukocyte Antigen (HLA) types were recorded. IL-15 gene polymorphisms rs2857261, rs10519613, and rs1057972 were analyzed through PCR. Results: There was a significantly higher frequency of GG genotype in rs2857972 polymorphisms and TT genotype in rs1057972 polymorphisms in celiac families compared to controls [41% vs. 23% (P = .0008), 36% vs. 11% (P = .001), respectively]. Without considering their HLA status, there was not any difference between celiacs and healthy siblings. However, when stratified according to their HLADQ2 status, rs2857972 GG polymorphism was 1.5 times prominent in celiacs than siblings at homozygous state, whereas rs1057972 TT genotype was found to be 2.5 times prominent in celiac siblings at heterozygous state. There was no association between these polymorphisms and clinical presentation. Conclusion: rs2857972 GG and rs1057972 TT variants of IL 15 are more prominent in celiac families than controls. However, the impact of IL-15 gene polymorphism on CD development is dependent on HLADQ2 status.en_US
dc.identifier.citationKara, Y., Eren, M., Arslan, S., & Çilingir, O. (2021). IL-15 Gene Polymorphism in Celiac Disease Patients and Their Siblings. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 32(4), 349–356. https://doi.org/10.5152/tjg.2021.19083en_US
dc.identifier.doi10.5152/tjg.2021.19083en_US
dc.identifier.endpage356en_US
dc.identifier.issue4en_US
dc.identifier.pmid34231481en_US
dc.identifier.scopus2-s2.0-85109259719en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2021.19083
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1920
dc.identifier.volume32en_US
dc.identifier.wosWOS:000670759200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEren, Makbule
dc.language.isoenen_US
dc.publisherTurkish Journal of Gastroenterologyen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeliac Diseaseen_US
dc.subjectIL-15en_US
dc.subjectGene Polymorphismen_US
dc.titleIL-15 gene polymorphism in celiac disease patients and their siblingsen_US
dc.typeArticleen_US

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