Interleukin-21 and interleukin-32 gene expression levels and their relationship with clinicopathological parameters in colorectal cancer

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dc.authoridMehmet Mahir Özmen / 0000-0003-0649-0111en_US
dc.authorscopusidMehmet Mahir Özmen / 57211511111en_US
dc.authorwosidMehmet Mahir Özmen / AAO-2321-2020en_US
dc.contributor.authorÖzmen, Füsun
dc.contributor.authorErdem, Gizem Övgü
dc.contributor.authorKulaçoğlu, Sezer
dc.contributor.authorÖzmen, Mehmet Mahir
dc.contributor.authorKansu, Emin
dc.date.accessioned2022-12-15T08:54:44Z
dc.date.available2022-12-15T08:54:44Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND AND AIMS: The immune cells in tumor microenvironment release chemokines and cytokines which determine the immune phenotype of the tumor and play an important role in the prognosis. Present study evaluates the gene expression levels of IL -21 and IL -32 and their relations to clinicopathologic parameters in colorectal cancer. PATIENTS AND METHODS: 31(17F) patients with colorectal cancer were included. Samples were obtained from normal and tumor tissues. After RNA isolation, IL -21 and IL -32 gene expression levels were measured. Immunohistochemistry was also carried out for CD4+, CD8+ and NKcells to measure cell density. The relations between expression levels, immune cell density and diffrentiation, stage, presence of vascular, perineural invasion and lymph node metastasis(MLN) were investigated. RESULTS: IL -32 gene expression levels were increased in tumor tissues. IL -21 levels were found to be decreased in 50% of the patients. IL -32 levels were also increased with the stage however, it was decreased significantly with the increased number of the MLIV. On the other hand, expression levels of IL -21 increased significantly with the presence of vascular invasion. CD4+ density was decreased with increased T-stage, vascular invasion whereas CD8+ density decreased only with the vascular invasion. CONCLUSIONS: IL -32 expressed by tumor microenvironment reveals that expression increased to control tumor growth, but levels are decreased with the increased number of MLNs which might be due to decreased CD4+ cell density. Changes on IL -21 and IL -32 together with the changes on immune cell density, indicate their role in tumor growth and invasion in colon cancer.en_US
dc.identifier.citationOzmen, F., Erdem, G. O., Kulacoglu, S., Ozmen, M., & Kansu, E. (2022). Interleukin-21 and Interleukin-32 gene expression levels and their relationship with clinicopathological parameters in colorectal cancer. Ann Ital Chir, 93(1), 78-87.en_US
dc.identifier.endpage87en_US
dc.identifier.issn0003-469Xen_US
dc.identifier.issn2239-253Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid35122427en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3483
dc.identifier.volume93en_US
dc.identifier.wosWOS:000886951900011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzmen, Mehmet Mahir
dc.language.isoenen_US
dc.publisherEDIZIONI LUIGI POZZIen_US
dc.relation.ispartofANNALI ITALIANI DI CHIRURGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/ClosedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectCytokinesen_US
dc.subjectImmune Cell Densityen_US
dc.subjectInterleukin-21en_US
dc.subjectInterleukin-32en_US
dc.subjectTumor Microenvironmenten_US
dc.titleInterleukin-21 and interleukin-32 gene expression levels and their relationship with clinicopathological parameters in colorectal canceren_US
dc.typeArticleen_US

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