The role of LncRNAs in translation
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.
Açıklama
Anahtar Kelimeler
Non-coding RNAs, Long Non-coding RNAs, NcRNAs, Translation, Cancer
Kaynak
Non-coding RNA
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
7
Sayı
16
Künye
Karakas, D.; Ozpolat, B. The Role of lncRNAs in Translation. Non-coding RNA 2021, 7, 16. https://doi.org/10.3390/ncrna7010016
