The role of LncRNAs in translation

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dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorwosidDidem Karakaş Zeybek / CAF-9974-2022
dc.contributor.authorKarakaş Zeybek, Didem
dc.contributor.authorÖzpolat, Bülent
dc.date.accessioned2021-03-08T13:38:26Z
dc.date.available2021-03-08T13:38:26Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractAbstract: Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.en_US
dc.identifier.citationKarakas, D.; Ozpolat, B. The Role of lncRNAs in Translation. Non-coding RNA 2021, 7, 16. https://doi.org/10.3390/ncrna7010016en_US
dc.identifier.doi10.3390/ncrna7010016en_US
dc.identifier.issue16en_US
dc.identifier.pmid33672592en_US
dc.identifier.scopus2-s2.0-85103333994en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.3390/ncrna7010016
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1516
dc.identifier.volume7en_US
dc.identifier.wosWOS:000633154300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarakaş Zeybek, Didem
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofNon-coding RNAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-coding RNAsen_US
dc.subjectLong Non-coding RNAsen_US
dc.subjectNcRNAsen_US
dc.subjectTranslationen_US
dc.subjectCanceren_US
dc.titleThe role of LncRNAs in translationen_US
dc.typeReview Articleen_US

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