Targeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignancies

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorPaskeh, Mahshid Deldar Abad
dc.contributor.authorAsadi, Shafagh
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorSaleki, Hossein
dc.contributor.authorKhoshbakht, Mohammad Amin
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2021-11-08T08:10:33Z
dc.date.available2021-11-08T08:10:33Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractAs a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/?-catenin, Sonic Hedgehog, Gli1 and NF-?B undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.citationDeldar Abad Paskeh, M., Asadi, S., Zabolian, A., Saleki, H., Khoshbakht, M. A., Sabet, S., ... & Sethi, G. (2021). Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies. International Journal of Molecular Sciences, 22(21), 11669.en_US
dc.identifier.doi10.3390/ijms222111669en_US
dc.identifier.endpage49en_US
dc.identifier.issue21en_US
dc.identifier.pmid34769099en_US
dc.identifier.scopus2-s2.0-85118235598en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms222111669
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2210
dc.identifier.volume22en_US
dc.identifier.wosWOS:000718506900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer Stem Cellsen_US
dc.subjectCancer Treatmenten_US
dc.subjectDrug Resistanceen_US
dc.subjectMedicinal Herbsen_US
dc.subjectMetastasisen_US
dc.subjectProliferationen_US
dc.titleTargeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignanciesen_US
dc.typeArticleen_US

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