Design, development and temporal evaluation of an MRI-compatible in-vitro circulation model using a compliant AAA phantom

Basit Öğe Kaydı
dc.authoridŞenol Pişkin / 0000-0002-8799-9472en_US
dc.authorscopusidŞenol Pişkin / 8636421200
dc.authorwosidŞenol Pişkin / JYJ-0063-2024
dc.contributor.authorThirugnanasambandam, Mirunalini
dc.contributor.authorCanch, Tejas
dc.contributor.authorPişkin, Şenol
dc.contributor.authorKarmonik, Christof
dc.contributor.authorKung, Ethan
dc.contributor.authorMenon, Prahlad
dc.contributor.authorAvril, Stephane
dc.contributor.authorFinol, Ender A
dc.date.accessioned2021-01-27T08:35:02Z
dc.date.available2021-01-27T08:35:02Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.description.abstractBiomechanical characterization of abdominal aortic aneurysms (AAA) has become commonplace in rupture risk assessment studies. However, its translation to the clinic has been greatly limited due to the complexity associated with its tools and their implementation. The unattainability of patient-specific tissue properties leads to the use of generalized population-averaged material models in finite element analyses, which adds a degree of uncertainty to the wall mechanics quantification. In addition, computational fluid dynamics modeling of AAA typically lacks the patient-specific inflow and outflow boundary conditions that should be obtained by non-standard of care clinical imaging. An alternative approach for analyzing AAA flow and sac volume changes is to conduct in vitro experiments in a controlled laboratory environment. We designed, built, and characterized quantitatively a benchtop flow-loop using a deformable AAA silicone phantom representative of a patient-specific geometry. The impedance modules, which are essential components of the flow-loop, were fine-tuned to ensure typical intra-sac pressure conditions. The phantom was imaged with a magnetic resonance imaging (MRI) scanner to acquire time-resolved images of the moving wall and the velocity field inside the sac. Temporal AAA sac volume changes lead to a corresponding variation in compliance throughout the cardiac cycle. The primary outcome of this work was the design optimization of the impedance elements, the quantitative characterization of the resistive and capacitive attributes of a compliant AAA phantom, and the exemplary use of MRI for flow visualization and quantification of the deformed AAA geometry.en_US
dc.identifier.citationThirugnanasambandam, M., Canchi, T., Piskin, S., Karmonik, C., Kung, E., Menon, P., Avril, S., & Finol, E. A. (2021). Design, Development and Temporal Evaluation of an MRI-Compatible In-Vitro Circulation Model Using a Compliant AAA Phantom. Journal of biomechanical engineering, 10.1115/1.4049894. Advance online publication. https://doi.org/10.1115/1.4049894en_US
dc.identifier.doi10.1115/1.4049894en_US
dc.identifier.pmid33493273en_US
dc.identifier.scopus2-s2.0-85107163621en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1115/1.4049894
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1377
dc.identifier.wosWOS:000639970700012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPişkin, Şenol
dc.language.isoenen_US
dc.publisherASME (American Society of Mechanical Engineers)en_US
dc.relation.ispartofJ. Biomech Eng.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDesign, development and temporal evaluation of an MRI-compatible in-vitro circulation model using a compliant AAA phantomen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Makine Mühendisliği Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu