Acute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent rats

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dc.authoridKübra Çelik / 0000-0002-0161-6179
dc.authorscopusidKübra Çelik / 57377969200
dc.authorwosidKübra Çelik / ABL-7797-2022
dc.contributor.authorÇelik, Kübra
dc.contributor.authorBilim, Petek
dc.contributor.authorGarip, Gurur
dc.contributor.authorDurmaz, Burak
dc.contributor.authorSozmen, Eser Yildirim
dc.contributor.authorBaka, Meral
dc.date.accessioned2021-12-06T08:01:48Z
dc.date.available2021-12-06T08:01:48Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Bölümüen_US
dc.description.abstractObjectives: The present study aimed to investigate the effects of acute hypoxia exposure following prenatal stress on the novelty-seeking behavior and hippocampus of adolescent rats. Methods: The offspring were divided into prenatal stress (PS) and non-stress (NS) groups. Both groups were exposed to hypoxia on postnatal day 10 (P10) while control groups were undisturbed. Novel object recognition task was performed in each group. Next, brains were collected to examine hippocampus via immunohistochemical and biochemical studies on postnatal day 35 (P35). Results: PS decreased novelty discrimination and synaptophysin (SYN) expressions both in CA1 & CA3 of the hypoxia group prominently (p<0.05). Nestin-expressing cells were reduced while vascular endothelial growth factor (VEGF) expression was enhanced in the subgranular zone (SGZ) of PS-hypoxia group (p<0.05). VEGF enhancement triggered angiogenesis in the CA1&CA3 significantly (p<0.05). PS also increased thiobarbituric acid reactive substances (TBARS) levels in the hypoxia group as a result of oxidative stress (p<0.05). Conclusion: These findings demonstrated that PS exacerbates neurodevelopmental deficits in the hippocampus of acute hypoxia-induced offspring in adolescence.en_US
dc.identifier.citationÇelik, K., Bilim, P., Garip, G., Durmaz, B., Yildirim Sözmen, E., & Baka, M. (2021). Acute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 10.1002/jdn.10162. Advance online publication.en_US
dc.identifier.doi10.1002/jdn.10162en_US
dc.identifier.pmid34850973en_US
dc.identifier.scopus2-s2.0-85121418079en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/jdn.10162
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2304
dc.identifier.wosWOS:000731829400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, Kübra
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHippocampusen_US
dc.subjectHypoxiaen_US
dc.subjectNovelty-seekingen_US
dc.subjectPrenatal Stressen_US
dc.titleAcute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent ratsen_US
dc.typeArticleen_US

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