Editing SOX genes by CRISPR-Cas: current insights and future perspectives

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorDehshahri, Ali
dc.contributor.authorBiagioni, Alessio
dc.contributor.authorBayat, Hadi
dc.contributor.authorLee, E. Hui Clarissa
dc.contributor.authorHashemabadi, Mohammad
dc.contributor.authorSamareh-Fekri, Hojjat
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2021-10-25T11:45:00Z
dc.date.available2021-10-25T11:45:00Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractClustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a substantial revolution has arisen in the genome engineering field. In recent years, CRISPR-Cas technology was rapidly developed and different types of DNA or RNA sequence editors, gene activator or repressor, and epigenome modulators established. The versatility and feasibility of CRISPR-Cas technology has introduced this system as the most suitable tool for discovering and studying the mechanism of specific genes and also for generating appropriate cell and animal models. SOX genes play crucial roles in development processes and stemness. To elucidate the exact roles of SOX factors and their partners in tissue hemostasis and cell regener-ation, generating appropriate in vitro and in vivo models is crucial. In line with these premises, CRISPR-Cas technology is a promising tool for studying different family members of SOX transcription factors. In this review, we aim to highlight the importance of CRISPR-Cas and summarize the applications of this novel, promising technology in studying and decoding the function of different members of the SOX gene family. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.en_US
dc.identifier.citationDehshahri A, Biagioni A, Bayat H, Lee EHC, Hashemabadi M, Fekri HS, Zarrabi A, Mohammadinejad R, Kumar AP. Editing SOX Genes by CRISPR-Cas: Current Insights and Future Perspectives. International Journal of Molecular Sciences. 2021; 22(21):11321. https://doi.org/10.3390/ijms222111321en_US
dc.identifier.doi10.3390/ijms222111321en_US
dc.identifier.issn1661-6596en_US
dc.identifier.issue21en_US
dc.identifier.pmid34768751en_US
dc.identifier.scopus2-s2.0-85117245168en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms222111321
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2168
dc.identifier.volume22en_US
dc.identifier.wosWOS:000719196000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectCRISPRen_US
dc.subjectGene Editingen_US
dc.subjectSOX Transcription Factorsen_US
dc.subjectStem Cellsen_US
dc.titleEditing SOX genes by CRISPR-Cas: current insights and future perspectivesen_US
dc.typeArticleen_US

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