Antiamoebic properties of ceftriaxone and zinc-oxide-cyclodextrin-conjugated ceftriaxone

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dc.authoridNaveed Ahmed Khan / 0000-0001-7667-8553en_US
dc.authoridRuqaiyyah Siddiqui / 0000-0001-9646-6208en_US
dc.authorscopusidNaveed Ahmed Khan / 7401797675en_US
dc.authorscopusidRuqaiyyah Siddiqui / 18635417000en_US
dc.authorwosidNaveed Ahmed Khan / FXL-5617-2022en_US
dc.authorwosidRuqaiyyah Siddiqui / FVT-1496-2022en_US
dc.contributor.authorMakhlouf, Zinb
dc.contributor.authorAkbar, Noor
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorShah, Muhammad Raza
dc.contributor.authorAlharbi, Ahmad M.
dc.contributor.authorAlfahemi, Hasan
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.date.accessioned2023-08-31T12:17:21Z
dc.date.available2023-08-31T12:17:21Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAcanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent. Accordingly, there is a pressing need for novel compounds. Nanotechnology has been gaining attention for enhancing drug delivery and reducing toxicity. Previous work has shown that various antibiotic classes displayed antiamoebic activity. Herein, we employed two antibiotics: ampicillin and ceftriaxone, conjugated with the nanocarrier zinc oxide and beta-cyclodextrin, and tested them against A. castellanii via amoebicidal, amoebistatic, encystment, excystment, cytopathogenicity, and cytotoxicity assays at a concentration of 100 mu g/mL. Notably, zinc oxide beta-cyclodextrin ceftriaxone significantly inhibited A. castellanii growth and cytopathogenicity. Additionally, both zinc oxide beta-cyclodextrin ceftriaxone and ceftriaxone markedly inhibited A. castellanii encystment. Furthermore, all the tested compounds displayed negligible cytotoxicity. However, minimal anti-excystment or amoebicidal effects were observed for the compounds. Accordingly, this novel nanoconjugation should be employed in further studies in hope of discovering novel anti-Acanthamoeba compounds.en_US
dc.identifier.citationMakhlouf, Z., Akbar, N., Khan, N. A., Shah, M. R., Alharbi, A. M., Alfahemi, H., & Siddiqui, R. (2022). Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone. Antibiotics, 11(12), 1721.en_US
dc.identifier.doi10.3390/antibiotics11121721en_US
dc.identifier.issn2079-6382en_US
dc.identifier.issue12en_US
dc.identifier.pmid36551378en_US
dc.identifier.scopus2-s2.0-85144694583en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/antibiotics11121721
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3968
dc.identifier.volume11en_US
dc.identifier.wosWOS:000902197800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKhan, Naveed Ahmed
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofAntibiotics-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcanthamoeba Castellaniien_US
dc.subjectZinc Oxideen_US
dc.subjectNanotechnologyen_US
dc.subjectDrug Discoveryen_US
dc.subjectCns Infectionsen_US
dc.subjectFree-Living Amoebaeen_US
dc.titleAntiamoebic properties of ceftriaxone and zinc-oxide-cyclodextrin-conjugated ceftriaxoneen_US
dc.typeArticleen_US

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