Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

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Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer Science and Business Media Deutschland GmbH

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Breast cancer (BC) is one of the most common cancers in females and is responsible for the highest cancer-related deaths following lung cancer. The complex tumor microenvironment and the aggressive behavior, heterogenous nature, high proliferation rate, and ability to resist treatment are the most well-known features of BC. Accordingly, it is critical to find an effective therapeutic agent to overcome these deleterious features of BC. Resveratrol (RES) is a polyphenol and can be found in common foods, such as pistachios, peanuts, bilberries, blueberries, and grapes. It has been used as a therapeutic agent for various diseases, such as diabetes, cardiovascular diseases, inflammation, and cancer. The anticancer mechanisms of RES in regard to breast cancer include the inhibition of cell proliferation, and reduction of cell viability, invasion, and metastasis. In addition, the synergistic effects of RES in combination with other chemotherapeutic agents, such as docetaxel, paclitaxel, cisplatin, and/or doxorubicin may contribute to enhancing the anticancer properties of RES on BC cells. Although, it demonstrates promising therapeutic features, the low water solubility of RES limits its use, suggesting the use of delivery systems to improve its bioavailability. Several types of nano drug delivery systems have therefore been introduced as good candidates for RES delivery. Due to RES’s promising potential as a chemopreventive and chemotherapeutic agent for BC, this review aims to explore the anticancer mechanisms of RES using the most up to date research and addresses the effects of using nanomaterials as delivery systems to improve the anticancer properties of RES. Graphical abstract: [Figure not available: see fulltext.].

Açıklama

Anahtar Kelimeler

Apoptosis, Breast Cancer, Drug Resistance, Nano-Scale Delivery, Radiotherapy, Resveratrol

Kaynak

Cellular and Molecular Life Sciences

WoS Q Değeri

Q1

Scopus Q Değeri

N/A

Cilt

79

Sayı

11

Künye

Behroozaghdam, M., Dehghani, M., Zabolian, A., Kamali, D., Javanshir, S., Hasani Sadi, F., . . . Bishayee, A. (2022). Resveratrol in breast cancer treatment: From cellular effects to molecular mechanisms of action. Cellular and Molecular Life Sciences, 79(11) doi:10.1007/s00018-022-04551-4