Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media Deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Breast cancer (BC) is one of the most common cancers in females and is responsible for the highest cancer-related deaths following lung cancer. The complex tumor microenvironment and the aggressive behavior, heterogenous nature, high proliferation rate, and ability to resist treatment are the most well-known features of BC. Accordingly, it is critical to find an effective therapeutic agent to overcome these deleterious features of BC. Resveratrol (RES) is a polyphenol and can be found in common foods, such as pistachios, peanuts, bilberries, blueberries, and grapes. It has been used as a therapeutic agent for various diseases, such as diabetes, cardiovascular diseases, inflammation, and cancer. The anticancer mechanisms of RES in regard to breast cancer include the inhibition of cell proliferation, and reduction of cell viability, invasion, and metastasis. In addition, the synergistic effects of RES in combination with other chemotherapeutic agents, such as docetaxel, paclitaxel, cisplatin, and/or doxorubicin may contribute to enhancing the anticancer properties of RES on BC cells. Although, it demonstrates promising therapeutic features, the low water solubility of RES limits its use, suggesting the use of delivery systems to improve its bioavailability. Several types of nano drug delivery systems have therefore been introduced as good candidates for RES delivery. Due to RES’s promising potential as a chemopreventive and chemotherapeutic agent for BC, this review aims to explore the anticancer mechanisms of RES using the most up to date research and addresses the effects of using nanomaterials as delivery systems to improve the anticancer properties of RES. Graphical abstract: [Figure not available: see fulltext.].
Açıklama
Anahtar Kelimeler
Apoptosis, Breast Cancer, Drug Resistance, Nano-Scale Delivery, Radiotherapy, Resveratrol
Kaynak
Cellular and Molecular Life Sciences
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
79
Sayı
11
Künye
Behroozaghdam, M., Dehghani, M., Zabolian, A., Kamali, D., Javanshir, S., Hasani Sadi, F., . . . Bishayee, A. (2022). Resveratrol in breast cancer treatment: From cellular effects to molecular mechanisms of action. Cellular and Molecular Life Sciences, 79(11) doi:10.1007/s00018-022-04551-4
