Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorBehroozaghdam, Mitra
dc.contributor.authorDehghani, Maryam
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorKamali, Davood
dc.contributor.authorJavanshir, Salar
dc.contributor.authorHasani Sadi, Farzaneh
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorTabari, Teimour
dc.contributor.authorRashidi, Mohsen
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorZarrabi, Ali
dc.contributor.authorDe Greef, Danielle
dc.contributor.authorBishayee, Anupam
dc.date.accessioned2022-11-08T13:38:21Z
dc.date.available2022-11-08T13:38:21Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractBreast cancer (BC) is one of the most common cancers in females and is responsible for the highest cancer-related deaths following lung cancer. The complex tumor microenvironment and the aggressive behavior, heterogenous nature, high proliferation rate, and ability to resist treatment are the most well-known features of BC. Accordingly, it is critical to find an effective therapeutic agent to overcome these deleterious features of BC. Resveratrol (RES) is a polyphenol and can be found in common foods, such as pistachios, peanuts, bilberries, blueberries, and grapes. It has been used as a therapeutic agent for various diseases, such as diabetes, cardiovascular diseases, inflammation, and cancer. The anticancer mechanisms of RES in regard to breast cancer include the inhibition of cell proliferation, and reduction of cell viability, invasion, and metastasis. In addition, the synergistic effects of RES in combination with other chemotherapeutic agents, such as docetaxel, paclitaxel, cisplatin, and/or doxorubicin may contribute to enhancing the anticancer properties of RES on BC cells. Although, it demonstrates promising therapeutic features, the low water solubility of RES limits its use, suggesting the use of delivery systems to improve its bioavailability. Several types of nano drug delivery systems have therefore been introduced as good candidates for RES delivery. Due to RES’s promising potential as a chemopreventive and chemotherapeutic agent for BC, this review aims to explore the anticancer mechanisms of RES using the most up to date research and addresses the effects of using nanomaterials as delivery systems to improve the anticancer properties of RES. Graphical abstract: [Figure not available: see fulltext.].en_US
dc.identifier.citationBehroozaghdam, M., Dehghani, M., Zabolian, A., Kamali, D., Javanshir, S., Hasani Sadi, F., . . . Bishayee, A. (2022). Resveratrol in breast cancer treatment: From cellular effects to molecular mechanisms of action. Cellular and Molecular Life Sciences, 79(11) doi:10.1007/s00018-022-04551-4en_US
dc.identifier.doi10.1007/s00018-022-04551-4en_US
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85139425274en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s00018-022-04551-4
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3274
dc.identifier.volume79en_US
dc.identifier.wosWOS:000863833000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofCellular and Molecular Life Sciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBreast Canceren_US
dc.subjectDrug Resistanceen_US
dc.subjectNano-Scale Deliveryen_US
dc.subjectRadiotherapyen_US
dc.subjectResveratrolen_US
dc.titleResveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of actionen_US
dc.typeReview Articleen_US

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