Relationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish population
Yükleniyor...
Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
C M B Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x(2)=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.
Açıklama
Anahtar Kelimeler
Mcp1 (-2518a > G), Single Nucleotide Polymorphism, Genetic Variability, Case-Control Study, Ovarian Cancer
Kaynak
Cellular and Molecular Biology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
63
Sayı
8
Künye
Attar, R., Yilmaz, S. G., Çakmakoglu, B., Duman, S., Yildirim, G., Görmüs, U., & Isbir, T. (2017). Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population. Cellular and Molecular Biology, 63(8), 100–103. https://doi.org/10.14715/cmb/2017.63.8.21
