Relationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish population

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dc.authoridUzay Görmüş / 0000-0002-3124-0184
dc.authorscopusidUzay Görmüş / 16230182400
dc.authorwosidUzay Görmüş / JKU-7676-2023
dc.contributor.authorAttar, R.
dc.contributor.authorYılmaz, S.G.
dc.contributor.authorÇakmakoğlu, B.
dc.contributor.authorDuman, S.
dc.contributor.authorYıldırım, G.
dc.contributor.authorGörmüş, Uzay
dc.contributor.authorİşbir, T.
dc.date.accessioned2020-08-30T20:08:15Z
dc.date.available2020-08-30T20:08:15Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x(2)=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.en_US
dc.identifier.citationAttar, R., Yilmaz, S. G., Çakmakoglu, B., Duman, S., Yildirim, G., Görmüs, U., & Isbir, T. (2017). Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population. Cellular and Molecular Biology, 63(8), 100–103. https://doi.org/10.14715/cmb/2017.63.8.21en_US
dc.identifier.doi10.14715/cmb/2017.63.8.21en_US
dc.identifier.endpage103en_US
dc.identifier.issn0145-5680en_US
dc.identifier.issn1165-158Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid28886321en_US
dc.identifier.scopus2-s2.0-85030544057en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.8.21
dc.identifier.urihttps://hdl.handle.net/20.500.12713/910
dc.identifier.volume63en_US
dc.identifier.wosWOS:000418145400021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGörmüş, Uzayen_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMcp1 (-2518a > G)en_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectGenetic Variabilityen_US
dc.subjectCase-Control Studyen_US
dc.subjectOvarian Canceren_US
dc.titleRelationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish populationen_US
dc.typeArticleen_US

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