Gallic acid for cancer therapy: molecular mechanisms and boosting efficacy by nanoscopical delivery

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorMilad, Ashrafizadeh
dc.contributor.authorAli, Zarrabi
dc.contributor.authorSepideh, Mirzaei
dc.contributor.authorFarid, Hashemi
dc.contributor.authorSaeed, Samarghandian
dc.date.accessioned2021-10-07T11:53:31Z
dc.date.available2021-10-07T11:53:31Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer. Plant-derived-natural products have poor bioavailability which restricts their anti-tumor activity. Gallic acid (GA) is a phenolic acid exclusively found in natural sources such as gallnut, sumac, tea leaves, and oak bark. In this review, we report on the most recent research related to anti-tumor activities of GA in various cancers with a focus on its underlying molecular mechanisms and cellular pathwaysthat that lead to apoptosis and migration of cancer cells. GA down-regulates the expression of molecular pathways involved in cancer progression such as PI3K/Akt. The co-administration of GA with chemotherapeutic agents shows improvements in suppressing cancer malignancy. Various nano-vehicles such as organic- and inorganic nano-materials have been developed for targeted delivery of GA at the tumor site. Here, we suggest that nano-vehicles improve GA bioavailability and its ability for tumor suppression.en_US
dc.identifier.citationAshrafizadeh, M., Zarrabi, A., Mirzaei, S., Hashemi, F., Samarghandian, S., Zabolian, A., Hushmandi, K., Ang, H. L., Sethi, G., Kumar, A. P., Ahn, K. S., Nabavi, N., Khan, H., Makvandi, P., & Varma, R. S. (2021). Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery. Food and Chemical Toxicology, 157. https://doi.org/10.1016/j.fct.2021.112576en_US
dc.identifier.doi10.1016/j.fct.2021.112576en_US
dc.identifier.endpage17en_US
dc.identifier.issn0278-6915en_US
dc.identifier.pmid34571052en_US
dc.identifier.scopus2-s2.0-85115981303en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2021.112576
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2129
dc.identifier.volume157en_US
dc.identifier.wosWOS:000706135600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGallic Aciden_US
dc.subjectCancer Treatmenten_US
dc.subjectMedicinal Herbsen_US
dc.subjectNano-scale Deliveryen_US
dc.subjectApoptosisen_US
dc.subjectMetastasisen_US
dc.titleGallic acid for cancer therapy: molecular mechanisms and boosting efficacy by nanoscopical deliveryen_US
dc.typeArticleen_US

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