Key actors in cancer therapy: epigenetic modifiers

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dc.authoridRemzi Okan Akar / 0000-0001-8687-2034en_US
dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridNazlıhan Aztopal / 0000-0003-3118-8061en_US
dc.authorscopusidRemzi Okan Akar / 57210603359
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidNazlıhan Aztopal / 55853882900
dc.authorscopusidSelin Selvi / 57210599688
dc.authorwosidRemzi Okan Akar / AAF-4576-2019
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidNazlıhan Aztopal / L-6687-2018
dc.authorwosidSelin Selvi / FZU-0996-2022
dc.contributor.authorAkar, Remzi Okan
dc.contributor.authorSelvi, Selin
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAztopal, Nazlıhan
dc.date.accessioned2020-08-30T20:07:07Z
dc.date.available2020-08-30T20:07:07Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractEpigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. It is known that alterations in the DNA methylation pattern and/or the loss of specific histone acetylation/methylation markers are related to several hallmarks of cancer, such as drug resistance, sternness, epithelial-mesenchymal transition, and metastasis. It has also recently been highlighted that epigenetic alterations are critical for the regulation of the stemlike properties of cancer cells (tumor-initiating cells; cancer stem cells). Cancer stem cells are thought to be responsible for the recurrence of cancer which makes the patient return to the clinic with metastatic tumor tissue. Hence, the dysregulation of epigenetic machinery represents potential new therapeutic targets. Therefore, compounds with epigenetic activities have become crucial for developing new therapy regimens (e.g., antimetastatic agents) in the fight against cancer. Here, we review the epigenetic modifiers that have already been used in the clinic and/or in clinical trials, related preclinical studies in cancer therapy, and the smart combination strategies that target cancer stem cells along with the other cancer cells. The emerging role of epitranscriptome (RNA epigenetic) in cancer therapy has also been included in this review as a new avenue and potential target for the better management of cancer-beneficial epigenetic machinery.en_US
dc.identifier.citationAkar, R. O., Selvi, S., Ulukaya, E., & Aztopal, N. (2019). Key actors in cancer therapy: epigenetic modifiers. Turkish Journal of Biology, 43(3), 155-170.en_US
dc.identifier.doi10.3906/biy-1903-39en_US
dc.identifier.endpage170en_US
dc.identifier.issn1300-0152en_US
dc.identifier.issn1303-6092en_US
dc.identifier.issue3en_US
dc.identifier.pmid31320814en_US
dc.identifier.scopus2-s2.0-85071138336en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.trdizinid336040en_US
dc.identifier.urihttps://doi.org/10.3906/biy-1903-39
dc.identifier.urihttps://hdl.handle.net/20.500.12713/697
dc.identifier.volume43en_US
dc.identifier.wosWOS:000471268100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkar, Remzi Okanen_US
dc.institutionauthorSelvi, Selinen_US
dc.institutionauthorUlukaya, Enginen_US
dc.institutionauthorAztopal, Nazlıhanen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpigenetic Modificationsen_US
dc.subjectRna Epigeneticen_US
dc.subjectAnticancer Drugsen_US
dc.subjectCancer Stem Cellsen_US
dc.titleKey actors in cancer therapy: epigenetic modifiersen_US
dc.typeReview Articleen_US

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