Current strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlook

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridFarzaneh Moghtader / 0009-0003-5988-6280
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidFerzaneh Mogtader / 57208552225
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.authorwosidFerzaneh Mogtader / DHD-9052-2022
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorMiccoli, Beatrice
dc.contributor.authorAvcı Adalı, Meltem
dc.contributor.authorMogtader, Ferzaneh
dc.contributor.authorSharifi, Fatemeh
dc.contributor.authorCecen, Berivan
dc.contributor.authorYaşayan, Gökçen
dc.contributor.authorBraeken, Dries
dc.contributor.authorAlarçin, Emine
dc.date.accessioned2020-08-30T20:07:44Z
dc.date.available2020-08-30T20:07:44Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractThe skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant endpoint for the application of pharmaceuticals. The area of in vitro skin tissue engineering has been progressing extensively in recent years. Advanced in vitro human skin models strongly impact the discovery of new drugs thanks to the enhanced screening efficiency and reliability. Nowadays, animal models are largely employed at the preclinical stage of new pharmaceutical compounds development for both risk assessment evaluation and pharmacokinetic studies. On the other hand, animal models often insufficiently foresee the human reaction due to the variations in skin immunity and physiology. Skin-on-chips devices offer innovative and state-of-the-art platforms essential to overcome these limitations. In the present review, we focus on the contribution of skin-on-chip platforms in fundamental research and applied medical research. In addition, we also highlighted the technical and practical difficulties that must be overcome to enhance skin-on-chip platforms, e. g. embedding electrical measurements, for improved modeling of human diseases as well as of new drug discovery and development.en_US
dc.identifier.citationBal-Öztürk, A., Miccoli, B., Avci-Adali, M., Mogtader, F., Sharifi, F., Çeçen, B., ... & Alarcin, E. (2018). Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook. Current pharmaceutical design, 24(45), 5437-5457.en_US
dc.identifier.doi10.2174/1381612825666190206195304en_US
dc.identifier.endpage5457en_US
dc.identifier.issn1381-6128en_US
dc.identifier.issn1873-4286en_US
dc.identifier.issue45en_US
dc.identifier.pmid30727878en_US
dc.identifier.scopus2-s2.0-85065092490en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5437en_US
dc.identifier.urihttps://doi.org/10.2174/1381612825666190206195304
dc.identifier.urihttps://hdl.handle.net/20.500.12713/821
dc.identifier.volume24en_US
dc.identifier.wosWOS:000468552000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBal Öztürk, Ayçaen_US
dc.institutionauthorMogtader, Ferzaneh
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSkin-On-Chipen_US
dc.subjectIn Vitro Skin Modelen_US
dc.subjectSkin Tissue Engineeringen_US
dc.subjectMicrofluidicen_US
dc.subjectDrug Discovery And Developmenten_US
dc.subjectSkin Impedanceen_US
dc.titleCurrent strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlooken_US
dc.typeReview Articleen_US

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