Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment. © 2022 Taylor & Francis Group, LLC.
Açıklama
Anahtar Kelimeler
Breast Cancer, Cancer Treatment, Film, Lung Cancer, Paclitaxel, Quality by Design
Kaynak
International Journal of Polymeric Materials and Polymeric Biomaterials
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Özcan Bülbül, E., Üstündağ Okur, N., Mısırlı, D., Cevher, E., Tsanaktsis, V., Bingöl Özakpınar, Ö., & Siafaka, P. I. (2022). Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, doi:10.1080/00914037.2022.2067538
