Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery

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dc.authoridEce Özcan Bülbül / 0000-0001-7112-923Xen_US
dc.authorscopusidEce Özcan Bülbül / 57211920637en_US
dc.authorwosidEce Özcan Bülbül / FZS-1598-2022
dc.contributor.authorÖzcan Bülbül, Ece
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorMısırlı, Duygu
dc.contributor.authorCevher, Erdal
dc.contributor.authorTsanaktsis, Vasilios
dc.contributor.authorBingöl Özakpınar, Özlem
dc.contributor.authorSiafaka, Panoraia I.
dc.date.accessioned2022-06-02T10:48:24Z
dc.date.available2022-06-02T10:48:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümüen_US
dc.description.abstractIn the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment. © 2022 Taylor & Francis Group, LLC.en_US
dc.identifier.citationÖzcan Bülbül, E., Üstündağ Okur, N., Mısırlı, D., Cevher, E., Tsanaktsis, V., Bingöl Özakpınar, Ö., & Siafaka, P. I. (2022). Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, doi:10.1080/00914037.2022.2067538en_US
dc.identifier.doi10.1080/00914037.2022.2067538en_US
dc.identifier.issn0091-4037en_US
dc.identifier.scopus2-s2.0-85130053009en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2022.2067538
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2787
dc.identifier.wosWOS:000787746200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzcan Bülbül, Ece
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectCancer Treatmenten_US
dc.subjectFilmen_US
dc.subjectLung Canceren_US
dc.subjectPaclitaxelen_US
dc.subjectQuality by Designen_US
dc.titleApplying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug deliveryen_US
dc.typeArticleen_US

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