Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury

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dc.authoridBora Gürer / 0000-0003-1500-6184en_US
dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / K-1177-2012
dc.contributor.authorKahveci, Fatih Ozan
dc.contributor.authorKahveci, Ramazan
dc.contributor.authorGökçe, Emre Cemal
dc.contributor.authorGökçe, Aysun
dc.contributor.authorKısa, Üçler
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorFesli, Ramazan
dc.contributor.authorSarı, Muhammed Fatih
dc.contributor.authorGürer, Bora
dc.date.accessioned2021-08-19T06:39:15Z
dc.date.available2021-08-19T06:39:15Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Lamotrigine, an anticonvulsant drug with inhibition properties of multi-ion channels, has been shown to be able to attenuates secondary neuronal damage by influencing different pathways. The aim of this study was to look into whether lamotrigine treatment could protect the spinal cord from experimental spinal cord ischemia-reperfusion injury. Materials and methods: Thirty-two rats, eight rats per group, were randomly assigned to the sham group in which only laparotomy was performed, and to the ischemia, methylprednisolone and lamotrigine groups, where the infrarenal aorta was clamped for thirty minutes to induce spinal cord ischemia-reperfusion injury. Tissue samples belonging to spinal cords were harvested from sacrificed animals twenty-four hours after reperfusion. Tumor necrosis factor-alpha levels, interleukin-1 beta levels, nitric oxide levels, superoxide dismutase activity, catalase activity, glutathione peroxidase activity, malondialdehyde levels and caspase-3 activity were studied. Light and electron microscopic evaluations were also performed to reveal the pathological alterations. Basso, Beattie, and Bresnahan locomotor scale and the inclined-plane test was used to evaluate neurofunctional status at the beginning of the study and just before the animals were sacrificed. Results: Lamotrigine treatment provided significant improvement in the neurofunctional status by preventing the increase in cytokine expression, increased lipid peroxidation and oxidative stress, depletion of antioxidant enzymes activity and increased apoptosis, all of which contributing to spinal cord damage through different paths after ischemia reperfusion injury. Furthermore, lamotrigine treatment has shown improved results concerning the histopathological and ultrastructural scores and the functional tests. Conclusion: These results proposed that lamotrigine may be a useful therapeutic agent to prevent the neuronal damage developing after spinal cord ischemia-reperfusion injury.en_US
dc.identifier.citationKahveci, F. O., Kahveci, R., Gokce, E. C., Gokce, A., Kısa, Ü., Sargon, M. F., Fesli, R., Sarı, M. F., & Gürer, B. (2021). Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury. Injury, S0020-1383(21)00679-3. Advance online publication. https://doi.org/10.1016/j.injury.2021.08.004en_US
dc.identifier.doi10.1016/j.injury.2021.08.004en_US
dc.identifier.pmid34391576en_US
dc.identifier.scopus2-s2.0-85112567539en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2021.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2004
dc.identifier.wosWOS:000715855800021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürer, Bora
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofInjuryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiinflammatoryen_US
dc.subjectAntiinflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectIschemia-reperfusion Injuryen_US
dc.subjectLamotrigineen_US
dc.subjectMethylprednisoloneen_US
dc.subjectNeuroprotectionen_US
dc.subjectRaten_US
dc.subjectSpinal Corden_US
dc.titleBiochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injuryen_US
dc.typeArticleen_US

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