Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)

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dc.authoridMurat Sütçü / 0000-0002-2078-9796en_US
dc.authoridDoruk Gül / 0000-0003-2558-3719
dc.authorscopusidMurat Sütçü / 55499199300en_US
dc.authorscopusidDoruk Gül / 57222108765
dc.authorwosidMurat Sütçü / ABG-7336-2021
dc.authorwosidDoruk Gül / AGJ-2448-2022
dc.contributor.authorYılmaz Çiftdoğan, Dilek
dc.contributor.authorEkemen Keleş, Yıldız
dc.contributor.authorKarbuz, Adem
dc.contributor.authorŞirvan Çetin, Benhur
dc.contributor.authorElmas Bozdemir, Şefika
dc.contributor.authorSütçü, Murat
dc.contributor.authorGül, Doruk
dc.date.accessioned2022-02-28T14:14:42Z
dc.date.available2022-02-28T14:14:42Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods: The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients' medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results: The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 ?g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion: The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.en_US
dc.identifier.citationYilmaz Ciftdogan D, Ekemen Keles Y, Karbuz A, Cetin BS, Elmas Bozdemir S, Kepenekli Kadayifci E, Metin Akcan O, Ozer A, Erat T, Sutcu M, Buyukcam A, Belet N, Erdeniz EH, Dalgic Karabulut N, Hancerli Torun S, Oncel S, Orbak Z, Turel O, Gayretli Aydin ZG, Kilic O, Yahsi A, Kara Aksay A, Ergenc Z, Petmezci MT, Oflaz MB, Sarikaya R, Otar Yener G, Ozen S, Gul D, Arslan G, Kara SS, Demirkol D, Yazici Ozkaya P, Yozgat Y, Varan C, Kara M, Arga G, Yakut N, Kilic AO, Cakici O, Kucuk M, Kaba O, Karaoglu Asrak H, Bursal Duramaz B, Dalkiran T, Berna Anil A, Turgut M, Karapinar B, Somer A, Elmali F, Dinleyici EC, Ciftci E, Kara A. Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study). J Paediatr Child Health. 2022 Feb 24.en_US
dc.identifier.doi10.1111/jpc.15913en_US
dc.identifier.issn1034-4810en_US
dc.identifier.issn1440-1754en_US
dc.identifier.pmid35199895en_US
dc.identifier.scopus2-s2.0-85125111465en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/jpc.15913
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2516
dc.identifier.wosWOS:000760265600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSütçü, Murat
dc.institutionauthorGül, Doruken_US
dc.language.isoenen_US
dc.relation.ispartofJ Paediatr Child Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectKawasaki Diseaseen_US
dc.subjectMIS-Cen_US
dc.subjectChilden_US
dc.subjectShocken_US
dc.titleMultisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)en_US
dc.typeArticleen_US

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