Dynamic contrast-enhanced MR perfusion in differentiation of benign and malignant brain lesions
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BENTHAM SCIENCE PUBL
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: We aimed to differentiate Glioblastoma Multiforme (GBM) from benign lesions like Developmental Venous Anomaly (DVA) and Cavernous Malformation (CM) by Dynamic Contrast-Enhanced MR Perfusion (DCE-MRP) markers such as Ktrans, Ve, Kep, and IAUC. Methods: We retrospectively evaluated 20 patients; 10 GBM as the malignant group, 5 CM and 5 DVA as the benign group. Ktrans, Kep, Ve, and IAUC parameters were measured by DCE-MRP, within the lesion, at perilesional nonenhancing white matter (PLWM) and contralateral normal appearing white matter (CLWM). Results: All benign and malignant lesions exhibited significantly increased Ktrans, Ve, and IAUC values compared to PLWM and CLWM (p < 0.001, p=0.006 and p<0.001). Subtracted Kep values between lesion and PLWM were significantly different between the benign and malignant groups, as the malignant group exhibited higher subtracted Kep values (p 0.035). For the malignant group; Ktrans and IAUC values at the lesion were positively correlated (r 0.911), while Kep and Ve at CLWM were negatively and strongly correlated (r 0.798). For the benign group; Ktrans with Ve and Ktrans with IAUC at lesion (r 0.708 and r 0.816 respectively), Ktrans and IAUC at PLWM (r 0.809), Ktrans and IAUC at CLWM(r 0.798) were strongly and positively correlated. Ktrans, Ve, and IAUC values can be used to restrict the lesion in both groups. Conclusion: Ktrans strongly correlates with IAUC and they can be used instead of each other in both benign and malignant lesions. Classical DCE-MRP parameters cannot be used in the differentiation of malignant lesions from benign vascular lesions. However, subtracted Kep values can be used to differentiate GBM from benign vascular lesions.
Açıklama
Anahtar Kelimeler
DCE-MR Perfusion, Glioblastome Multiforme, Cavernous Malformation, Developmental Venous Anomaly, Ktrans, Subtracted Kep
Kaynak
CURRENT MEDICAL IMAGING
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
18
Sayı
10
Künye
Cetinkaya, E., Aralasmak, A., Atasoy, B., Tokdemir, S., Toprak, H., Toprak, A., Kurtcan, S., Alkan, A. (2022). Dynamic contrast-enhanced MR perfusion in differentiation of benign and malignant brain lesions. Current Medical Imaging, 18(10), 1099-1105.
