Dynamic contrast-enhanced MR perfusion in differentiation of benign and malignant brain lesions

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dc.authoridAyşe Aralaşmak / 0000-0001-8654-855Xen_US
dc.authorscopusidAyşe Aralaşmak / 6507596742
dc.authorwosidAyşe Aralaşmak / Y-5820-2018en_US
dc.contributor.authorÇetinkaya, Ezra
dc.contributor.authorAralaşmak, Ayşe
dc.contributor.authorAtasoy, Bahar
dc.contributor.authorTokdemir, Sevil
dc.contributor.authorToprak, Hüseyin
dc.contributor.authorToprak, Ali
dc.contributor.authorKurtcan, Serpil
dc.contributor.authorAlkan, Alpay
dc.date.accessioned2022-09-19T14:10:09Z
dc.date.available2022-09-19T14:10:09Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: We aimed to differentiate Glioblastoma Multiforme (GBM) from benign lesions like Developmental Venous Anomaly (DVA) and Cavernous Malformation (CM) by Dynamic Contrast-Enhanced MR Perfusion (DCE-MRP) markers such as Ktrans, Ve, Kep, and IAUC. Methods: We retrospectively evaluated 20 patients; 10 GBM as the malignant group, 5 CM and 5 DVA as the benign group. Ktrans, Kep, Ve, and IAUC parameters were measured by DCE-MRP, within the lesion, at perilesional nonenhancing white matter (PLWM) and contralateral normal appearing white matter (CLWM). Results: All benign and malignant lesions exhibited significantly increased Ktrans, Ve, and IAUC values compared to PLWM and CLWM (p < 0.001, p=0.006 and p<0.001). Subtracted Kep values between lesion and PLWM were significantly different between the benign and malignant groups, as the malignant group exhibited higher subtracted Kep values (p 0.035). For the malignant group; Ktrans and IAUC values at the lesion were positively correlated (r 0.911), while Kep and Ve at CLWM were negatively and strongly correlated (r 0.798). For the benign group; Ktrans with Ve and Ktrans with IAUC at lesion (r 0.708 and r 0.816 respectively), Ktrans and IAUC at PLWM (r 0.809), Ktrans and IAUC at CLWM(r 0.798) were strongly and positively correlated. Ktrans, Ve, and IAUC values can be used to restrict the lesion in both groups. Conclusion: Ktrans strongly correlates with IAUC and they can be used instead of each other in both benign and malignant lesions. Classical DCE-MRP parameters cannot be used in the differentiation of malignant lesions from benign vascular lesions. However, subtracted Kep values can be used to differentiate GBM from benign vascular lesions.en_US
dc.identifier.citationCetinkaya, E., Aralasmak, A., Atasoy, B., Tokdemir, S., Toprak, H., Toprak, A., Kurtcan, S., Alkan, A. (2022). Dynamic contrast-enhanced MR perfusion in differentiation of benign and malignant brain lesions. Current Medical Imaging, 18(10), 1099-1105.en_US
dc.identifier.doi10.2174/1573405618666220324112457en_US
dc.identifier.endpage1105en_US
dc.identifier.issn1573-4056en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85137118216en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1099en_US
dc.identifier.urihttps://doi.org/10.2174/1573405618666220324112457
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3161
dc.identifier.volume18en_US
dc.identifier.wosWOS:000851377100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAralaşmak, Ayşe
dc.language.isoenen_US
dc.publisherBENTHAM SCIENCE PUBLen_US
dc.relation.ispartofCURRENT MEDICAL IMAGINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDCE-MR Perfusionen_US
dc.subjectGlioblastome Multiformeen_US
dc.subjectCavernous Malformationen_US
dc.subjectDevelopmental Venous Anomalyen_US
dc.subjectKtransen_US
dc.subjectSubtracted Kepen_US
dc.titleDynamic contrast-enhanced MR perfusion in differentiation of benign and malignant brain lesionsen_US
dc.typeArticleen_US

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