Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers

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Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Academic Press Inc Elsevier Science

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Advancements in genomic technologies have ushered application of innovative changes into biomedical sciences and clinical medicine. Consequently, these changes have created enormous opportunities to implement precision population/occupational disease prevention and target-specific disease intervention (or personalized medicine). To capture the opportunities, however, it is necessary is to develop novel, especially genomic-based, biomarkers which can provide precise and individualized health risk assessment. In this review, development of the Challenge-comet assay is used as an example to demonstrate how assays need to be validated for its sensitivity, specificity, and functional and quantitative features, and how assays can be used to provide individualized health risk assessment for precision prevention and intervention. Other examples of genomic-based novel biomarkers will also be discussed. Furthermore, no biomarkers can be used alone therefore their integrated usage with other biomarkers and with personal data bases will be discussed.

Açıklama

Anahtar Kelimeler

Dna Damage And Repair Response, Challenge Assay, Comet/Hcomet Assay, Occupational Exposure, Personalized Risk Assessment, Disease Prevention

Kaynak

Toxicology and Applied Pharmacology

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

397

Sayı

Künye

Xu, J., Sram, R. J., Cebulska-Wasilewska, A., Miloradov, M. V., Sardas, S., & Au, W. W. (2020). Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers. Toxicology and Applied Pharmacology, 115011.