Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers

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dc.authoridSemra Şardaş / 0000-0001-5456-8636en_US
dc.authorscopusidSemra Şardaş / 7003286974
dc.authorwosidSemra Şardaş / J-2175-2018
dc.contributor.authorXu, Jianzhen
dc.contributor.authorSram, Radim J.
dc.contributor.authorCebulska-Wasilewska, Antonina
dc.contributor.authorMiloradov, Mirjana, V
dc.contributor.authorŞardaş, Semra
dc.contributor.authorAu, William W.
dc.date.accessioned2020-08-30T20:06:09Z
dc.date.available2020-08-30T20:06:09Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractAdvancements in genomic technologies have ushered application of innovative changes into biomedical sciences and clinical medicine. Consequently, these changes have created enormous opportunities to implement precision population/occupational disease prevention and target-specific disease intervention (or personalized medicine). To capture the opportunities, however, it is necessary is to develop novel, especially genomic-based, biomarkers which can provide precise and individualized health risk assessment. In this review, development of the Challenge-comet assay is used as an example to demonstrate how assays need to be validated for its sensitivity, specificity, and functional and quantitative features, and how assays can be used to provide individualized health risk assessment for precision prevention and intervention. Other examples of genomic-based novel biomarkers will also be discussed. Furthermore, no biomarkers can be used alone therefore their integrated usage with other biomarkers and with personal data bases will be discussed.en_US
dc.description.sponsorshipUniversity of Medicine, Pharmacy, Sciences and Technology, Romania; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673037]; Healthy Aging in Industrial Environment from the Czech Ministry of Education [HAIE CZ.02.1.01/0.0/0.0/16_019/0000798]; EUEuropean Union (EU); EU-Cost ActionEuropean Union (EU)European Cooperation in Science and Technology (COST) [CA 15129]en_US
dc.description.sponsorshipThis work was supported by internal funding to WWA from the University of Medicine, Pharmacy, Sciences and Technology, Romania; by grants from the National Natural Science Foundation of China (grant number No. 81673037) to JZX and by the Healthy Aging in Industrial Environment grant HAIE CZ.02.1.01/0.0/0.0/16_019/0000798 from the Czech Ministry of Education and EU to RJS. This project is a part of the EU-Cost Action, CA 15129 (DiMoPEx).en_US
dc.identifier.citationXu, J., Sram, R. J., Cebulska-Wasilewska, A., Miloradov, M. V., Sardas, S., & Au, W. W. (2020). Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers. Toxicology and Applied Pharmacology, 115011.en_US
dc.identifier.doi10.1016/j.taap.2020.115011en_US
dc.identifier.issn0041-008Xen_US
dc.identifier.issn1096-0333en_US
dc.identifier.pmid32305282en_US
dc.identifier.scopus2-s2.0-85083528999en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.taap.2020.115011
dc.identifier.urihttps://hdl.handle.net/20.500.12713/389
dc.identifier.volume397en_US
dc.identifier.wosWOS:000533634300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞardaş, Semraen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofToxicology and Applied Pharmacologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDna Damage And Repair Responseen_US
dc.subjectChallenge Assayen_US
dc.subjectComet/Hcomet Assayen_US
dc.subjectOccupational Exposureen_US
dc.subjectPersonalized Risk Assessmenten_US
dc.subjectDisease Preventionen_US
dc.titleChallenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workersen_US
dc.typeReview Articleen_US

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