Can serum matrix metalloproteinase-9 and SMAD-2 levels predict lamina propria invasion in bladder urothelial carcinoma?
| dc.authorid | Yasin Yitgin / 0000-0003-1111-6941 | en_US |
| dc.authorscopusid | Yasin Yitgin / 56562977600 | |
| dc.authorwosid | Yasin Yitgin / ABE-9487-2020 | |
| dc.contributor.author | Yitgin, Yasin | |
| dc.contributor.author | Erdem, Selcuk | |
| dc.contributor.author | Serilmez, Murat | |
| dc.contributor.author | Duranyildiz , Derya | |
| dc.contributor.author | Verep, Samed | |
| dc.contributor.author | Gasimov, Kamranbay | |
| dc.contributor.author | Tefik, Tzevat | |
| dc.contributor.author | Sanli, Oner | |
| dc.contributor.author | Ozcan, Faruk | |
| dc.date.accessioned | 2021-05-18T08:47:35Z | |
| dc.date.available | 2021-05-18T08:47:35Z | |
| dc.date.issued | 2021 | en_US |
| dc.department | İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
| dc.description.abstract | Introduction: Matrix metalloproteinase-9 (MMP-9) has a role in the destruction of lamina propria (LP) of the bladder wall and SMAD-2 promotes cell-to-cell adhesion. This study aimed to investigate the association between LP invasion and serum protein and mRNA expression levels of MMP-9 and SMAD-2 in bladder cancer (BC) patients. Methods: Serum samples were taken from 57 patients with suspicious BC before TUR-BT (Group 1) and 20 patients with benign diseases as control (Group 2). The mRNA expression and serum protein levels of MMP-9 and SMAD-2 were analyzed using Real-Time PCR and ELISA methods, respectively. The comparison of protein and mRNA expression levels of MMP-9 and SMAD-2 were done statistically between Group 1 and 2, as well as for different T stages of BC. Results: The protein levels of MMP-9 (2448 vs 637.5 pg/mL, P = .0001) and SMAD-2 (6.85 vs 1.61 P = .0001) were significantly higher in Group 1 compared to Group 2. The mRNA expression levels of MMP-9 (P = .89) and SMAD-2 (P = .99) did not significantly differ between the groups. The protein levels of MMP-9 in T1 patients were significantly higher from both of pTa patients (P = .018) and pT2 (P = .02). The protein levels of SMAD-2 were not statistically different between T stages. Similarly, the mRNA expression levels of MMP-9 and SMAD-2 were not different between T stages. Conclusions: The protein levels of MMP-9 and SMAD-2 were increased in BC patients while mRNA expressions were not different. Furthermore, the increased protein level of MMP-9 in T1 patients was more pronounced which may be related to LP invasion of the tumor. | en_US |
| dc.identifier.citation | Yitgin, Y., Erdem, S., Serilmez, M., Duranyıldız, D., Verep, S., Gasimov, K., Tefik, T., Sanli, O., & Ozcan, F. (2021). Can serum matrix metalloproteinase-9 and SMAD-2 levels predict lamina propria invasion in bladder urothelial carcinoma?. International journal of clinical practice, e14277. Advance online publication. https://doi.org/10.1111/ijcp.14277 | en_US |
| dc.identifier.doi | 10.1111/ijcp.14277 | en_US |
| dc.identifier.issn | 1742-1241 | en_US |
| dc.identifier.pmid | 33928727 | en_US |
| dc.identifier.scopus | 2-s2.0-85105654161 | en_US |
| dc.identifier.scopusquality | Q2 | en_US |
| dc.identifier.uri | https://doi.org/10.1111/ijcp.14277 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12713/1737 | |
| dc.identifier.wos | WOS:000649828100001 | en_US |
| dc.identifier.wosquality | Q2 | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.institutionauthor | Yitgin, Yasin | |
| dc.language.iso | en | en_US |
| dc.publisher | WILEY | en_US |
| dc.relation.ispartof | International Journal of Clinical Practice | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Can serum matrix metalloproteinase-9 and SMAD-2 levels predict lamina propria invasion in bladder urothelial carcinoma? | en_US |
| dc.type | Article | en_US |
