Comparison of similar cells: mesenchymal stromal cells and fibroblasts
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier GmbH
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts are one of the most abundant cell types with the ability to maintain homeostasis. Because of the promising properties of MSCs, they have been well studied and their differentiation potentials, immunomodulatory potentials, gene expression profiles are identified. It has been observed that fibroblasts and mesenchymal stromal cells have similar morphology, gene expression patterns, surface markers, proliferation, differentiation, and immunomodulatory capacities. Thus, it is hard to distinguish these two cell types. Epigenetic signatures, i.e., methylation patterns of cells, are the only usable promising difference between them. Such significant similarities show that these two cells may be related to each other.
Açıklama
Anahtar Kelimeler
Cell Surface Markers, Differentiation, Fibroblasts, Gene Expression, Mesenchymal Stromal Cells, Proliferation
Kaynak
Acta Histochemica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
122
Sayı
8
Künye
Ugurlu, B., & Karaoz, E. (2020). Comparison of similar cells: Mesenchymal stromal cells and fibroblasts. Acta Histochemica, 122(8), 151634.
