Non-coding RNAs and macrophage interaction in tumor progression
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by affecting various molecular pathways, they modulate tumor progression and therapy response. The lncRNAs can affect miRNAs via sponging and other molecular pathways to modulate macrophage polarization. A few experiments have also examined role of circRNAs in targeting signaling networks and affecting macrophages. The therapeutic targeting of these ncRNAs can mediate TME remodeling and affect macrophage polarization. Furthermore, exosomal ncRNAs derived from tumor cells or macrophages can modulate polarization and TME remodeling. Suppressing biogenesis and secretion of exosomes can inhibit ncRNA-mediated M2 polarization of macrophages and prevent tumor progression. The ncRNAs, especially exosomal ncRNAs can be considered as non-invasive biomarkers for tumor diagnosis. © 2022 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Cancer Therapy, CircRNAs, Drug Resistance, Exosomes, Long non-coding RNAs, MiRNAs
Kaynak
Critical Reviews in Oncology/Hematology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
173
Sayı
Künye
Entezari, M., Sadrkhanloo, M., Rashidi, M., Asnaf, S. E., Taheriazam, A., Hashemi, M., . . . Sethi, G. (2022). Non-coding RNAs and macrophage interaction in tumor progression. Critical Reviews in oncology/hematology, 173 doi:10.1016/j.critrevonc.2022.103680
