Non-coding RNAs and macrophage interaction in tumor progression

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorSadrkhanloo, Mehrdokht
dc.contributor.authorRashidi, Mohsen
dc.contributor.authorAsnaf, Sholeh Etehad
dc.contributor.authorTaheriazam, Afshin
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorRabiee, Navid
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorSethi, Gautam
dc.date.accessioned2022-05-18T13:18:29Z
dc.date.available2022-05-18T13:18:29Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by affecting various molecular pathways, they modulate tumor progression and therapy response. The lncRNAs can affect miRNAs via sponging and other molecular pathways to modulate macrophage polarization. A few experiments have also examined role of circRNAs in targeting signaling networks and affecting macrophages. The therapeutic targeting of these ncRNAs can mediate TME remodeling and affect macrophage polarization. Furthermore, exosomal ncRNAs derived from tumor cells or macrophages can modulate polarization and TME remodeling. Suppressing biogenesis and secretion of exosomes can inhibit ncRNA-mediated M2 polarization of macrophages and prevent tumor progression. The ncRNAs, especially exosomal ncRNAs can be considered as non-invasive biomarkers for tumor diagnosis. © 2022 Elsevier B.V.en_US
dc.identifier.citationEntezari, M., Sadrkhanloo, M., Rashidi, M., Asnaf, S. E., Taheriazam, A., Hashemi, M., . . . Sethi, G. (2022). Non-coding RNAs and macrophage interaction in tumor progression. Critical Reviews in oncology/hematology, 173 doi:10.1016/j.critrevonc.2022.103680en_US
dc.identifier.doi10.1016/j.critrevonc.2022.103680en_US
dc.identifier.issn1040-8428en_US
dc.identifier.scopus2-s2.0-85127965864en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.critrevonc.2022.103680
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2669
dc.identifier.volume173en_US
dc.identifier.wosWOS:000797907700002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofCritical Reviews in Oncology/Hematologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Therapyen_US
dc.subjectCircRNAsen_US
dc.subjectDrug Resistanceen_US
dc.subjectExosomesen_US
dc.subjectLong non-coding RNAsen_US
dc.subjectMiRNAsen_US
dc.titleNon-coding RNAs and macrophage interaction in tumor progressionen_US
dc.typeReview Articleen_US

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