Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in rats

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dc.authoridMustafa Necati Dağlı /0000-0002-3220-8848
dc.authorscopusidMustafa Necati Dağlı / 57198041499
dc.authorwosidMustafa Necati Dağlı / CLN-6582-2022
dc.contributor.authorAdıyaman, M.S.
dc.contributor.authorAdiyaman O.A.
dc.contributor.authorDagli, A.F.
dc.contributor.authorKarahan, M.Z.
dc.contributor.authorDağlı, Mustafa Necati
dc.date.accessioned2022-01-31T08:10:55Z
dc.date.available2022-01-31T08:10:55Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Doxorubicin (DOX) is an anthracycline cytotoxic chemotherapeutic drug that is commonly used in cancer treatment. A major side effect limiting the clinical use of DOX is cardiotoxicity due to oxidative injury. Nigella sativa (NS) is an annual flowering plant with antioxidant properties. Its seeds contain several bioactive constituents such as saturated and unsaturated fatty acids, thymoquinone, dithymoquinone, thymohydroquinone, and thymol. In this study, we investigated the effect of NS extract on DOX-induced cardiotoxicity. Methods: The experimental study animals consisted of 28 male Sprague Dawley rats weighing between 300 and 400 g. Four study groups each of seven rats were defined: controls; NS extract; DOX; and DOX+NS. Control and DOX rats received standard food, while each rat in the NS and DOX+NS groups also received 100 mg/kg NS extract orally. At day 28 of follow-up, rats in the DOX groups were administered a single 10 mg/kg intraperitoneal dose of DOX, while rats in the control and NS groups received a single 10 mg/kg dose of physiological saline solution. All animals were monitored for 35 days. On day 35, the rats were decapitated and serum and cardiac tissue samples were obtained. Troponin and NT-proBNP levels were measured in blood sera, while malondialdehyde (MDA), nitric oxide, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were quantified in sera and tissue samples. Histological alterations that were assessed in cardiac tissue included myocyte disarray, small vessel disease, myocyte hypertrophy, and fibrosis. Results: The DOX group had significantly higher NT-proBNP, TOS, and MDA, with greater histopathological derangement. TAC was significantly elevated in the DOX+NS group, which also exhibited significantly lower troponin, TOS, and MDA, as well as significantly higher TAC compared to the DOX group. Histopathological examination showed that the significant structural derangement observed in DOX rats was markedly and significantly reduced in DOX+NS rats. Conclusion: Our results suggest that NS extract may prevent DOX-induced cardiotoxicity and thus represents a promising cardioprotective agent. © 2021 Sociedade Portuguesa de Cardiologiaen_US
dc.identifier.citationAdıyaman, M. Ş., Adıyaman, Ö. A., Dağlı, A. F., Karahan, M. Z., & Dağlı, M. N. (2022). Prevention of doxorubicin-induced experimental cardiotoxicity by nigella sativa in rats. [Prevenção da cardiotoxicidade da doxorrubicina pela Nigella sativa em ratos] Revista Portuguesa De Cardiologia, doi:10.1016/j.repc.2020.12.015en_US
dc.identifier.doi10.1016/j.repc.2020.12.015en_US
dc.identifier.issn0870-2551en_US
dc.identifier.scopus2-s2.0-85119917311en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.repc.2020.12.015
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2443
dc.identifier.wosWOS:000759495000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağlı, Mustafa Necati
dc.language.isoenen_US
dc.publisherSociedade Portuguesa de Cardiologiaen_US
dc.relation.ispartofRevista Portuguesa de Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectDoxorubicinen_US
dc.subjectNigella Sativaen_US
dc.subjectOxidative Stressen_US
dc.subjectThymoquinoneen_US
dc.titlePrevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in ratsen_US
dc.title.alternativePrevenção da cardiotoxicidade da doxorrubicina pela Nigella sativa em ratosen_US
dc.typeArticleen_US

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