Coronary microvascular dysfunction is common in patients hospitalized with COVID-19 infection

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dc.authoridTolga Sinan Güvenç / 0000-0002-6738-266Xen_US
dc.authorscopusidTolga Sinan Güvenç / 6602421975
dc.authorwosidTolga Sinan Güvenç / AAK-6020-2020en_US
dc.contributor.authorAtıcı, Adem
dc.contributor.authorÇalışkan, Mustafa
dc.contributor.authorBaycan, Ömer Faruk
dc.contributor.authorÇelik, Fatma Betül
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorÇağ, Yasemin
dc.contributor.authorKonal, Oğuz
dc.contributor.authorBilgili, Ümmühan Zeynep
dc.contributor.authorAğırbaşlı, Mehmet Ali
dc.contributor.authorIrgı, Tuğçe
dc.date.accessioned2022-05-23T08:04:36Z
dc.date.available2022-05-23T08:04:36Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Aims: Microvascular disease is considered as one of the main drivers of morbidity and mortality in severe COVID-19, and microvascular dysfunction has been demonstrated in the subcutaneous and sublingual tissues in COVID-19 patients. The presence of coronary microvascular dysfunction (CMD) has also been hypothe-sized, but direct evidence demonstrating CMD in COVID-19 patients is missing. In the present study, we aimed to investigate CMD in patients hospitalized with COVID-19, and to understand whether there is a relationship between biomarkers of myocardial injury, myocardial strain and inflammation and CMD.Methods:39 patients that were hospitalized with COVID-19 and 40 control subjects were included to the present study. Biomarkers for myocardial injury, myocardial strain, inflammation, and fibrin turnover were obtained at admission. A comprehen-sive echocardiographic examination, including measurement of coronary flow veloc -ity reserve (CFVR), was done after the patient was stabilized.Results:Patients with COVID-19 infection had a significantly lower hyperemic cor -onary flow velocity, resulting in a significantly lower CFVR (2.0 ± 0.3 vs. 2.4 ± 0.5, p< .001). Patients with severe COVID-19 had a lower CFVR compared to those with moderate COVID-19 (1.8 ± 0.2 vs. 2.2 ± 0.2, p< .001) driven by a trend toward higher basal flow velocity. CFVR correlated with troponin (p= .003, r: ?.470), B- type natriu-retic peptide (p< .001, r: ?.580), C- reactive protein (p< .001, r: ?.369), interleukin-6 (p< .001, r: ?.597), and d- dimer (p< .001, r: ?.561), with the three latter biomarkers having the highest areas-under- curve for predicting CMD.Conclusions:Coronary microvascular dysfunction is common in patients with COVID-19 and is related to the severity of the infection. CMD may also explain the “cryptic” myocardial injury seen in patients with severe COVID-19 infection.en_US
dc.identifier.citationAtıcı A, Çağ Y, Konal O, İrgi T, Bilgili ÜZ, Ağırbaşlı MA. Coronary microvascular dysfunction is common in patients hospitalized with COVID-19 infection. Microcirculation. 2022 Apr 18:e12757. doi: 10.1111/micc.12757. Epub ahead of print. PMID: 35437863.en_US
dc.identifier.doi10.1111/micc.12757en_US
dc.identifier.issn1549-8719en_US
dc.identifier.pmid35437863en_US
dc.identifier.scopus2-s2.0-85129600572en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1111/micc.12757
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2699
dc.identifier.wosWOS:000789845200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüvenç, Tolga Sinan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicrocurcilationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS- COV-2en_US
dc.subjectCoronary Microvascular Dysfunctionen_US
dc.subjectEchocardiographyen_US
dc.subjectMyocardial Injuryen_US
dc.titleCoronary microvascular dysfunction is common in patients hospitalized with COVID-19 infectionen_US
dc.typeArticleen_US

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