New indicator of cellular ischemia in coronary slow-flow phenomenon: cell-free DNA

Yükleniyor...
Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Turkish Society of Cardiology

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to the distal vascular bed in at least 1 major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood once released from nucleated cells. The aim of this study was to determine if the level of cfDNA, which is an indicator of ischemia at the cellular level, was increased in CSFP. Methods: The study included 46 patients in total: 23 patients with CSFP and 23 with a normal coronary angiogram (NCA). The level of cfDNA, and clinical, biochemical, and angiographic features of the groups were compared. Results: The mean age was 53.8±10.3 years for the CSFP patient group and 56.6±9.4 years for the NCA patient group. There was no statistically significant difference between the groups in terms of basal clinical characteristics or laboratory data. The plasma cfDNA level was 5.04±2.37 ng/µL in the CSFP patients and 2.28±1.09 ng/µL in the NCA group (p<0.001). Conclusion: Several invasive and noninvasive studies conducted on patients with CSFP have revealed myocardial ischemia. The results of this study demonstrated that the level of cfDNA was significantly increased in patients with CSFP as a result of ischemia at the cellular level caused by microvascular disruption. © 2020 Turkish Society of Cardiology

Açıklama

Anahtar Kelimeler

Cell-free Nucleic Acids, Coronary Slow Flow Phenomenon, Myocardial Ischemia

Kaynak

Turk Kardiyoloji Dernegi Arsivi

WoS Q Değeri

N/A

Scopus Q Değeri

Q4

Cilt

48

Sayı

6

Künye

Yolcu, M., Dogan, A., Kurtoglu, N., Hancer, V. S., & Gürbüzel, M. (2020). New indicator of cellular ischemia in coronary slow-flow phenomenon: Cell-free DNA. Archives of the Turkish Society of Cardiology, 48(6), 558-565.