New indicator of cellular ischemia in coronary slow-flow phenomenon: cell-free DNA

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dc.authoridVeysel Sabri Hançer / 0000-0003-2994-1077en_US
dc.authorscopusidVeysel Sabri Hançer / 6506533543
dc.authorwosidVeysel Sabri Hançer / X-8971-2018
dc.contributor.authorYolcu, M.
dc.contributor.authorDoğan, A.
dc.contributor.authorKurtoğlu, N.
dc.contributor.authorHançer, V.S.
dc.contributor.authorGürbüzel, M
dc.date.accessioned2020-09-16T06:36:00Z
dc.date.available2020-09-16T06:36:00Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Coronary slow-flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to the distal vascular bed in at least 1 major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in the blood once released from nucleated cells. The aim of this study was to determine if the level of cfDNA, which is an indicator of ischemia at the cellular level, was increased in CSFP. Methods: The study included 46 patients in total: 23 patients with CSFP and 23 with a normal coronary angiogram (NCA). The level of cfDNA, and clinical, biochemical, and angiographic features of the groups were compared. Results: The mean age was 53.8±10.3 years for the CSFP patient group and 56.6±9.4 years for the NCA patient group. There was no statistically significant difference between the groups in terms of basal clinical characteristics or laboratory data. The plasma cfDNA level was 5.04±2.37 ng/µL in the CSFP patients and 2.28±1.09 ng/µL in the NCA group (p<0.001). Conclusion: Several invasive and noninvasive studies conducted on patients with CSFP have revealed myocardial ischemia. The results of this study demonstrated that the level of cfDNA was significantly increased in patients with CSFP as a result of ischemia at the cellular level caused by microvascular disruption. © 2020 Turkish Society of Cardiologyen_US
dc.identifier.citationYolcu, M., Dogan, A., Kurtoglu, N., Hancer, V. S., & Gürbüzel, M. (2020). New indicator of cellular ischemia in coronary slow-flow phenomenon: Cell-free DNA. Archives of the Turkish Society of Cardiology, 48(6), 558-565.en_US
dc.identifier.doi10.5543/tkda.2020.45605en_US
dc.identifier.endpage565en_US
dc.identifier.issn1016-5169en_US
dc.identifier.issue6en_US
dc.identifier.pmid32955030en_US
dc.identifier.scopus2-s2.0-85090490183en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage558en_US
dc.identifier.trdizinid383292en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1022
dc.identifier.volume48en_US
dc.identifier.wosWOS:000579484800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHançer, Veysel Sabri
dc.language.isoenen_US
dc.publisherTurkish Society of Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell-free Nucleic Acidsen_US
dc.subjectCoronary Slow Flow Phenomenonen_US
dc.subjectMyocardial Ischemiaen_US
dc.titleNew indicator of cellular ischemia in coronary slow-flow phenomenon: cell-free DNAen_US
dc.title.alternativeKoroner yavaş akım fenomeninde hücresel iskemi için yeni gösterge: serbest DNAen_US
dc.typeArticleen_US

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