Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Science

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Recent progress in vascular growth mechanics has involved the use of computational algorithms toaddress clinical problems with the use of three-dimensional patient specific geometries. The objectiveof this study is to establish a predictive computational model for the volumetric growth of pulmonaryarterial (PA) tissue following complex cardiovascular patch reconstructive surgeries for congenital heartdisease patients. For the first time in the literature, the growth mechanics and performance of artificialcardiovascular patches in contact with the growing PA tissue domain is established. An elastic-growing material model was developed in the open source FEBio software suite to first examine the sur-gical patch reconstruction process for an idealized main PA anatomy as a benchmark model and then forthe patient-specific PA of a newborn. Following patch reconstruction, high levels of stress and strain arecompensated by growth on the arterial tissue. As this growth progresses, the arterial tissue is predicted tostiffen to limit elastic deformations. We simulated this arterial growth up to the age of 18 years, whensomatic growth plateaus. Our research findings show that the non-growing patch material remains ina low strain state throughout the simulation timeline, while experiencing high stress hot-spots.Arterial tissue growth along the surgical stitch lines is triggered mainly due to PA geometry and bloodpressure, rather than due to material property differences in the artificial and native tissue. Thus, non-uniform growth patterns are observed along the arterial tissue proximal to the sutured boundaries.This computational approach is effective for the pre-surgical planning of complex patch surgeries toquantify the unbalanced growth of native arteries and artificial non-growing materials to develop opti-mal patch biomechanics for improved postoperative outcomes.

Açıklama

PubMed: 3540217

Anahtar Kelimeler

Patient-specific Surgical Planning, Vascular Growth, Tissue Remodeling, Patch Reconstruction, Congenital Heart Disease

Kaynak

Journal of Biomechanics

WoS Q Değeri

Q3

Scopus Q Değeri

Q1

Cilt

117

Sayı

Künye

Lashkarinia, S. S., Coban, G., Kose, B., Salihoglu, E., & Pekkan, K. (2021). Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions. Journal of biomechanics, 117, 110274. Advance online publication. https://doi.org/10.1016/j.jbiomech.2021.110274