Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions

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dc.authoridGürsan Çoban / 0000-0001-8057-8408en_US
dc.authorscopusidÇoban Gürsan / 26421561000
dc.contributor.authorLashkarinia, S. Samaneh
dc.contributor.authorÇoban, Gürsan
dc.contributor.authorKöse, Banu
dc.contributor.authorSalihoğlu, Ece
dc.contributor.authorPekkan, Kerem
dc.date.accessioned2021-02-08T07:44:49Z
dc.date.available2021-02-08T07:44:49Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Yazılım Mühendisliği Bölümüen_US
dc.descriptionPubMed: 3540217en_US
dc.description.abstractRecent progress in vascular growth mechanics has involved the use of computational algorithms toaddress clinical problems with the use of three-dimensional patient specific geometries. The objectiveof this study is to establish a predictive computational model for the volumetric growth of pulmonaryarterial (PA) tissue following complex cardiovascular patch reconstructive surgeries for congenital heartdisease patients. For the first time in the literature, the growth mechanics and performance of artificialcardiovascular patches in contact with the growing PA tissue domain is established. An elastic-growing material model was developed in the open source FEBio software suite to first examine the sur-gical patch reconstruction process for an idealized main PA anatomy as a benchmark model and then forthe patient-specific PA of a newborn. Following patch reconstruction, high levels of stress and strain arecompensated by growth on the arterial tissue. As this growth progresses, the arterial tissue is predicted tostiffen to limit elastic deformations. We simulated this arterial growth up to the age of 18 years, whensomatic growth plateaus. Our research findings show that the non-growing patch material remains ina low strain state throughout the simulation timeline, while experiencing high stress hot-spots.Arterial tissue growth along the surgical stitch lines is triggered mainly due to PA geometry and bloodpressure, rather than due to material property differences in the artificial and native tissue. Thus, non-uniform growth patterns are observed along the arterial tissue proximal to the sutured boundaries.This computational approach is effective for the pre-surgical planning of complex patch surgeries toquantify the unbalanced growth of native arteries and artificial non-growing materials to develop opti-mal patch biomechanics for improved postoperative outcomes.en_US
dc.identifier.citationLashkarinia, S. S., Coban, G., Kose, B., Salihoglu, E., & Pekkan, K. (2021). Computational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructions. Journal of biomechanics, 117, 110274. Advance online publication. https://doi.org/10.1016/j.jbiomech.2021.110274en_US
dc.identifier.doi10.1016/j.jbiomech.2021.110274en_US
dc.identifier.issn0021-9290en_US
dc.identifier.pmid3540217en_US
dc.identifier.scopus2-s2.0-85100167905en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbiomech.2021.110274
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1421
dc.identifier.volume117en_US
dc.identifier.wosWOS:000626266300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇoban, Gürsan
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.ispartofJournal of Biomechanicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPatient-specific Surgical Planningen_US
dc.subjectVascular Growthen_US
dc.subjectTissue Remodelingen_US
dc.subjectPatch Reconstructionen_US
dc.subjectCongenital Heart Diseaseen_US
dc.titleComputational modeling of vascular growth in patient-specific pulmonary arterial patch reconstructionsen_US
dc.typeArticleen_US

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