Real life experience regarding clinical characteristics and treatment outcome in non-cutaneous peripheral t cell lymphomas: A multicenter study of Turkish hematology research and education group (threg)
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gelanos
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Peripheral T-NK-cell lymphomas (PTCL) are uncommon, quite heterogeneous group of disorders, and representing only 10–15% of all non-Hodgkin lymphomas (NHL). Although both molecular and clinical studies have been increased in recent years, we have still little knowledge regarding the real-life practice on PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes in a large population-based cohort of patients presenting with systemic non-cutaneous PTCL patients. Material and methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate (ORR) was 65.9% with 49.4% complete remission (CR) (n=81) and 16.5% partial response (PR) (n=27). The 5-year OS and EFS rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033), respectively. Conclusion: Current retrospective large real-life data analysis of Turkish experience regarding the non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts, with some minor differences in terms of survival and transplantation outcomes compared to existent experience. The long-term outcome of patients who received autologous hematopoietic cell transplantation as part of upfront consolidation or salvage is favorable compared to patients who were unable to receive high-dose therapy.
Açıklama
Anahtar Kelimeler
Kaynak
Turkish Journal of Hematology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Kayıkçı Ö, Mehtap Ö, Sarı İ, Demirkan F, Beyan C, Çetin G, Vural F, Yılmaz M, Öztürk E, Akpınar S, Eser B, Gündüz M, Büyükaşık Y, Payzın B, Yıldırım R, Doğu MH, Özkan A, Kelkitli E, Tekgündüz E. Real Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T Cell Lymphomas: A Multicenter Study of Turkish Hematology Research and Education Group (Threg). Turk J Haematol. 2022 Jun 9. doi: 10.4274/tjh.galenos.2022.2022.0052. Epub ahead of print. PMID: 35678126.
