Real life experience regarding clinical characteristics and treatment outcome in non-cutaneous peripheral t cell lymphomas: A multicenter study of Turkish hematology research and education group (threg)

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dc.authoridRahşan Yıldırım / 0000-0003-3156-9067
dc.authorscopusidRahşan Yıldırım / 23988125700
dc.authorwosidRahşan Yıldırım / GKE-1453-2022
dc.contributor.authorKayıkçı, Ömür
dc.contributor.authorÖzgür, Mehtap
dc.contributor.authorSarı, İsmail
dc.contributor.authorDemirkan, Fatih
dc.contributor.authorBeyan, Cengiz
dc.contributor.authorGüven, Çetin
dc.contributor.authorVural, Filiz
dc.contributor.authorYılmaz, Mehmet
dc.contributor.authorÖztürk, Erman
dc.contributor.authorAkpınar, Seval
dc.contributor.authorEser, Bülent
dc.contributor.authorGündüz, Mehmet
dc.contributor.authorBüyükaşık, Yahya
dc.contributor.authorPayzın, Bahriye
dc.contributor.authorYıldırım, Rahşan
dc.contributor.authorDoğu, Mehmet Hilmi
dc.contributor.authorÖzkan, Atilla
dc.contributor.authorKelkitli, Engin
dc.contributor.authorTekgündüz, Emre
dc.date.accessioned2022-07-25T13:41:15Z
dc.date.available2022-07-25T13:41:15Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Peripheral T-NK-cell lymphomas (PTCL) are uncommon, quite heterogeneous group of disorders, and representing only 10–15% of all non-Hodgkin lymphomas (NHL). Although both molecular and clinical studies have been increased in recent years, we have still little knowledge regarding the real-life practice on PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes in a large population-based cohort of patients presenting with systemic non-cutaneous PTCL patients. Material and methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate (ORR) was 65.9% with 49.4% complete remission (CR) (n=81) and 16.5% partial response (PR) (n=27). The 5-year OS and EFS rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033), respectively. Conclusion: Current retrospective large real-life data analysis of Turkish experience regarding the non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts, with some minor differences in terms of survival and transplantation outcomes compared to existent experience. The long-term outcome of patients who received autologous hematopoietic cell transplantation as part of upfront consolidation or salvage is favorable compared to patients who were unable to receive high-dose therapy.en_US
dc.identifier.citationKayıkçı Ö, Mehtap Ö, Sarı İ, Demirkan F, Beyan C, Çetin G, Vural F, Yılmaz M, Öztürk E, Akpınar S, Eser B, Gündüz M, Büyükaşık Y, Payzın B, Yıldırım R, Doğu MH, Özkan A, Kelkitli E, Tekgündüz E. Real Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T Cell Lymphomas: A Multicenter Study of Turkish Hematology Research and Education Group (Threg). Turk J Haematol. 2022 Jun 9. doi: 10.4274/tjh.galenos.2022.2022.0052. Epub ahead of print. PMID: 35678126.en_US
dc.identifier.doi10.4274/tjh.galenos.2022.2022.0052en_US
dc.identifier.issn1300-7777en_US
dc.identifier.pmid35678126en_US
dc.identifier.scopus2-s2.0-85137000431en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.trdizinid1127363en_US
dc.identifier.urihttp://doi.org/10.4274/tjh.galenos.2022.2022.0052
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3043
dc.identifier.wosWOS:000883473800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYıldırım, Rahşan
dc.language.isoenen_US
dc.publisherGelanosen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleReal life experience regarding clinical characteristics and treatment outcome in non-cutaneous peripheral t cell lymphomas: A multicenter study of Turkish hematology research and education group (threg)en_US
dc.typeArticleen_US

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