The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Soc Stem Cell Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Cerebral Palsy (CP) is the most common motor disability reason of childhood that occurs secondarily to non-progressive damage in the brain whose development is still ongoing. Methods: 6-year-old dystonic-spastic male CP patient received allogenic mesenchymal stem cells treatment four times as 1x10(6)/kg in intrathecal and intravenous administration of Umbilical Cord-derived mesenchymal stem cells (UC-MSCs) ways. Before and after the treatment, the patient was followed-up with FIM (Functional Independent Measurement), GMFCS (Gross Motor Function Classification System 88), Tardieu Scale, TCMS (Trunk Control Measurement Scale), MACS (Manual Ability Classification Scale), CFSS (Communication Function Classification System) for 18 months and received intensive rehabilitation. Results: Improvements were observed especially in functional scales except for the Tardieu Scale, and no adverse effects were detected aside from a slight pain in the back. Conclusion: Wider future case studies on UC-MSCs will enable us to assess the efficacy of UC-MSCs which have positive impacts especially on functional scales.
Açıklama
Anahtar Kelimeler
Cerebral Palsy, Mesenchymal Stem Cell, Rehabilitation
Kaynak
International Journal of Stem Cells
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
11
Sayı
1
Künye
Okur, S. Ç., Erdoğan, S., Demir, C. S., Günel, G., & Karaöz, E. (2018). The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report. International journal of stem cells, 11(1), 141.
