The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authoridCansu Subaşı Demir / 0000-0003-4429-0989
dc.authoridGülşen Günel / 0000-0003-1574-0231
dc.authoridSinan Erdoğan / 0000-0002-8517-3925
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorscopusidGülşen Günel / 57202685676
dc.authorscopusidSinan Erdoğan / 55954339600
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.authorwosidCansu Subaşı Demir / IBW-2017-2023
dc.authorwosidGülşen Günel / ABF-8146-2021
dc.authorwosidSinan Erdoğan / GZA-9556-2022
dc.contributor.authorOkur, Sibel Çağlar
dc.contributor.authorErdoğan, Sinan
dc.contributor.authorSubaşı Demir, Cansu
dc.contributor.authorGünel, Gülşen
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2020-08-30T20:07:34Z
dc.date.available2020-08-30T20:07:34Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Cerebral Palsy (CP) is the most common motor disability reason of childhood that occurs secondarily to non-progressive damage in the brain whose development is still ongoing. Methods: 6-year-old dystonic-spastic male CP patient received allogenic mesenchymal stem cells treatment four times as 1x10(6)/kg in intrathecal and intravenous administration of Umbilical Cord-derived mesenchymal stem cells (UC-MSCs) ways. Before and after the treatment, the patient was followed-up with FIM (Functional Independent Measurement), GMFCS (Gross Motor Function Classification System 88), Tardieu Scale, TCMS (Trunk Control Measurement Scale), MACS (Manual Ability Classification Scale), CFSS (Communication Function Classification System) for 18 months and received intensive rehabilitation. Results: Improvements were observed especially in functional scales except for the Tardieu Scale, and no adverse effects were detected aside from a slight pain in the back. Conclusion: Wider future case studies on UC-MSCs will enable us to assess the efficacy of UC-MSCs which have positive impacts especially on functional scales.en_US
dc.identifier.citationOkur, S. Ç., Erdoğan, S., Demir, C. S., Günel, G., & Karaöz, E. (2018). The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report. International journal of stem cells, 11(1), 141.en_US
dc.identifier.doi10.15283/ijsc17077en_US
dc.identifier.endpage147en_US
dc.identifier.issn2005-3606en_US
dc.identifier.issn2005-5447en_US
dc.identifier.issue1en_US
dc.identifier.pmid29699386en_US
dc.identifier.scopus2-s2.0-85049050236en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.15283/ijsc17077
dc.identifier.urihttps://hdl.handle.net/20.500.12713/790
dc.identifier.volume11en_US
dc.identifier.wosWOS:000433396400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdoğan, Sinanen_US
dc.institutionauthorSubaşı Demir, Cansuen_US
dc.institutionauthorGünel, Gülşenen_US
dc.institutionauthorKaraöz, Erdalen_US
dc.language.isoenen_US
dc.publisherKorean Soc Stem Cell Researchen_US
dc.relation.ispartofInternational Journal of Stem Cellsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebral Palsyen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectRehabilitationen_US
dc.titleThe effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case reporten_US
dc.typeArticleen_US

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