Association of CDH1 -160 C ? A and -347 G? GA polymorphisms and expression of E-cadherin and gastric cancer: a case-control study

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dc.authoridMustafa Hasbahçeci / 0000-0002-5468-5338en_US
dc.authorscopusidMustafa Hasbahçeci / 6505757663
dc.authorwosidMustafa Hasbahçeci / ABG-1763-2020
dc.contributor.authorAkçakaya, Adem
dc.contributor.authorÜnver, Nurcan
dc.contributor.authorKırış Aydogan, Tuğba
dc.contributor.authorGüzel, Mehmet
dc.contributor.authorAkçakaya, Fatma Betül
dc.contributor.authorÇakmakoğlu, Bedia
dc.contributor.authorHasbahçeci, Mustafa
dc.date.accessioned2021-05-21T12:54:58Z
dc.date.available2021-05-21T12:54:58Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The loss of function of the E-cadherin (CDH1) gene with -160 C -> A and -347 G -> GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer. Material and Methods: Gastric adenocarcinoma patients and individuals with benign gastric pathologies were included in this case-control study. Demographic data and pathological findings were recorded. Immunohistochemical staining of E-cadherin expression and analysis of -160 C -> A and -347 G -> GA polymorphisms were done. Differences between allele frequencies of -160 C -> A and -347 G -> GA polymorphisms and expression of E-cadherin were the primary outcomes. Results: There were 78 gastric cancer patients (Group A) and 113 individuals with benign gastric pathologies (Group B). The number of male patients and mean age were higher in Group A (p< 0.001). -160 C -> A and 347 G -> GA polymorphisms and their allelic distributions showed no difference between the groups (p>0.05 for all). There was a significant association between -160 C -> A polymorphism and grade of E-cadherin expression (p=0.013). There were no significant differences between survival rates with -160 C -> A, 347 G -> GA and intensity of E-cadherin expression (p>0.05 for all). There was no significant association between -160 C -> A and -347 G -> GA polymorphisms and gastric cancer. Conclusion: There was no impact of E-cadherin expression on tumoral features and survival in gastric cancer. -160 C -> A polymorphism may influence the expression of E-cadherin in gastric cancer.en_US
dc.identifier.doi10.47717/turkjsurg.2021.5097en_US
dc.identifier.endpage48en_US
dc.identifier.issn2564-6850en_US
dc.identifier.issn2564-7032en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85108798589en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage41en_US
dc.identifier.trdizinid503803en_US
dc.identifier.urihttps://doi.org/10.47717/turkjsurg.2021.5097
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1748
dc.identifier.volume37en_US
dc.identifier.wosWOS:000644916100009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHasbahçeci, Mustafa
dc.language.isoenen_US
dc.publisherTURKISH SURGICAL ASSOCen_US
dc.relation.ispartofTURKISH JOURNAL OF SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCdh1 Polymorphismsen_US
dc.subjectE-Cadherinen_US
dc.subjectGastric Carcinomaen_US
dc.subjectImmunohistochemical Expressionen_US
dc.subjectSurvival C-160a Promoter Polymorphismen_US
dc.subjectGermline Mutationsen_US
dc.subjectGeneen_US
dc.subjectRisken_US
dc.subjectPatternen_US
dc.titleAssociation of CDH1 -160 C ? A and -347 G? GA polymorphisms and expression of E-cadherin and gastric cancer: a case-control studyen_US
dc.typeArticleen_US

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