Relationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot study
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sbem-Soc Brasil Endocrinologia & Metabologia
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Activated macrophages (M1-type macrophages) in adipose tissue secrete many proinflammatory cytokines that induce insulin resistance (IR). Oncostatin M (OSM), a member of the interleukin-6 (1.6) family of Gp130 cytokines, plays an important role in a variety of biological functions, including the regulation of inflammatory responses. Proinflammatory cytokines released in patients with IR trigger a chronic, low-grade inflammatory reaction in blood vessel walls. This inflammator response leads to endothelial damage, which is the main mechanism for atherosclerosis and many cardiovascular diseases. Animal studies have reported a relationship between OSM and IR. To the best of our knowledge, however, few clinical studies have examined this topic.Therefore, we studied the relationship between serum levels of OSM and IR. Subjects and methods: This prospective cross-sectional case-control study enrolled 50 people with IR (according to the HOMA IR and QUICKI indices) and 34 healthy controls. The fasting blood concentrations of insulin, glucose, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, C-reactive protein (CRP), and OSM were determined. Results: There were no significant differences between the two groups in age, sex, and HbA1c levels. Univariate analyses showed that waist circumference (WC) and levels of fasting glucose, insulin, CRP, HDL-C, OSM, HOMA-IR, and QUICKI differed between the two study groups. In multivariate analyses, both IR indices (QUICKI and HOMA) and OSM differed between the two groups. Conclusion. OSM was correlated with the IR indices (QUICKI and HOMA). For simplicity, it might replace the other IR indices in the future. Further detailed studies are needed to confirm this.
Açıklama
Hursitoglu, Mehmet/0000-0002-9062-118X; TOPRAK, Zeki/0000-0002-7411-3628; UGURLUKISI, BILAL/0000-0003-3954-7161; Erdem, Mustafa Genco/0000-0002-7783-8130; AYDIN YOLDEMIR, Şengül/0000-0003-4236-1181
Anahtar Kelimeler
Diabetes Mellitus, Insulin Resistance, Oncostatin M, Metabolic Syndrome
Kaynak
Archives of Endocrinology Metabolism
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
64
Sayı
1
Künye
Akarsu, M., Hursitoglu, M., Toprak, Z., Yoldemir, S. A., Altun, O., Toprak, I. D., … Tukek, T. (2020). Relationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot study. ARCHIVES OF ENDOCRINOLOGY METABOLISM, 64(1), 38–44. https://doi.org/10.20945/2359-3997000000176
