Relationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot study

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dc.authoridMustafa Genco Erdem / 0000-0002-7783-8130
dc.authorscopusidMustafa Genco Erdem / 56684619200
dc.authorwosidMustafa Genco Erdem / S-2964-2017
dc.contributor.authorAkarsu, Murat
dc.contributor.authorHurşitoğlu, Mehmet
dc.contributor.authorToprak, Zeki
dc.contributor.authorYoldemir, Şengül Aydın
dc.contributor.authorAltun, Özgür
dc.contributor.authorToprak, İlkim Deniz
dc.contributor.authorÖzcan, Mustafa
dc.contributor.authorYürüyen, Gülden
dc.contributor.authorUğurlukişi, Bilal
dc.contributor.authorErdem, Mustafa Genco
dc.contributor.authorKirna, Kerem
dc.contributor.authorDemir, Pınar
dc.contributor.authorÇapar, Gazi
dc.contributor.authorArman, Yücel
dc.contributor.authorTukek, Tufan
dc.date.accessioned2020-08-30T20:06:19Z
dc.date.available2020-08-30T20:06:19Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.descriptionHursitoglu, Mehmet/0000-0002-9062-118X; TOPRAK, Zeki/0000-0002-7411-3628; UGURLUKISI, BILAL/0000-0003-3954-7161; Erdem, Mustafa Genco/0000-0002-7783-8130; AYDIN YOLDEMIR, Şengül/0000-0003-4236-1181en_US
dc.description.abstractObjective: Activated macrophages (M1-type macrophages) in adipose tissue secrete many proinflammatory cytokines that induce insulin resistance (IR). Oncostatin M (OSM), a member of the interleukin-6 (1.6) family of Gp130 cytokines, plays an important role in a variety of biological functions, including the regulation of inflammatory responses. Proinflammatory cytokines released in patients with IR trigger a chronic, low-grade inflammatory reaction in blood vessel walls. This inflammator response leads to endothelial damage, which is the main mechanism for atherosclerosis and many cardiovascular diseases. Animal studies have reported a relationship between OSM and IR. To the best of our knowledge, however, few clinical studies have examined this topic.Therefore, we studied the relationship between serum levels of OSM and IR. Subjects and methods: This prospective cross-sectional case-control study enrolled 50 people with IR (according to the HOMA IR and QUICKI indices) and 34 healthy controls. The fasting blood concentrations of insulin, glucose, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, C-reactive protein (CRP), and OSM were determined. Results: There were no significant differences between the two groups in age, sex, and HbA1c levels. Univariate analyses showed that waist circumference (WC) and levels of fasting glucose, insulin, CRP, HDL-C, OSM, HOMA-IR, and QUICKI differed between the two study groups. In multivariate analyses, both IR indices (QUICKI and HOMA) and OSM differed between the two groups. Conclusion. OSM was correlated with the IR indices (QUICKI and HOMA). For simplicity, it might replace the other IR indices in the future. Further detailed studies are needed to confirm this.en_US
dc.identifier.citationAkarsu, M., Hursitoglu, M., Toprak, Z., Yoldemir, S. A., Altun, O., Toprak, I. D., … Tukek, T. (2020). Relationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot study. ARCHIVES OF ENDOCRINOLOGY METABOLISM, 64(1), 38–44. https://doi.org/10.20945/2359-3997000000176en_US
dc.identifier.doi10.20945/2359-3997000000176en_US
dc.identifier.endpage44en_US
dc.identifier.issn2359-3997en_US
dc.identifier.issn2359-4292en_US
dc.identifier.issue1en_US
dc.identifier.pmid31576964en_US
dc.identifier.scopus2-s2.0-85081750751en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000176
dc.identifier.urihttps://hdl.handle.net/20.500.12713/471
dc.identifier.volume64en_US
dc.identifier.wosWOS:000532470300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdem, Mustafa Gencoen_US
dc.language.isoenen_US
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologiaen_US
dc.relation.ispartofArchives of Endocrinology Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectInsulin Resistanceen_US
dc.subjectOncostatin Men_US
dc.subjectMetabolic Syndromeen_US
dc.titleRelationships among oncostatin M, insulin resistance, and chronic inflammation: a pilot studyen_US
dc.typeArticleen_US

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