Boric acid-impregnated silk fibroin/gelatin/hyaluronic acid-based films for improving the wound healing process
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal of Applied Polymer Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Recently, with the progression in wound dressings, the importance of the biocompatible material with enhanced features for potential applications in the biomedical field has been more developed. Current strategies focus on the acceleration of the wound healing by systematically designed dressing materials. In this study, biocompatible hydrogel films with the combination of silk fibroin, hyaluronic acid and gelatin biopolymers were fabricated. To gain the enhanced wound healing behavior of wound dressings, boric acid (BA) was formulated in various ratios. The prepared hydrogel films were characterized in terms of FTIR, TGA, DSC, and SEM analysis. Following to the swelling and mechanical tests, in vitro biocompatibility and wound healing tests were performed against L929 fibroblast cell line. Results suggest that the presence of 1% (wt/vol) BA in the formulation of silk fibroin/gelatin/hyaluronic acid based hydrogel films is the key in providing such an enhanced mechanical and wound healing feature and may offer an alternative approach for wound healing treatment. © 2021 Wiley Periodicals LLC.
Açıklama
Anahtar Kelimeler
Differential Scanning Calorimetry, Films, Mechanical Properties, Thermogravimetric Analysis
Kaynak
Wiley
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Özen, N., Özbaş, Z., İzbudak, B., (...), Özkahraman, B., Bal-Öztürk, A. (2021). Boric acid-impregnated silk fibroin/gelatin/hyaluronic acid-based films for improving the wound healing process. Journal of Applied Polymer Science. https://doi.org/10.1002/app.51715.
